Chapter 2 Receptor tyrosine kinase B-mediated excitatory synaptogenesis

B. W. Luikart, L. F. Parada

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

The receptor tyrosine kinase B, TrkB, is the high-affinity receptor for brain-derived neurotrophic factor (BDNF). Much evidence supports a role for TrkB signaling in excitatory synapse formation. There have been a number of recent advances in understanding the cell biology of TrkB-mediated excitatory synaptogenesis. The predominant mechanism by which TrkB supports excitatory synaptogenesis appears to be due to cell-autonomous signaling in both pre- and postsynaptic cells. This signaling appears to contribute to the growth and stabilization processes necessary for the net formation of synapses during development. Further, the molecular mechanisms by which TrkB contributes to these growth and stabilization processes are beginning to be elucidated.

Original languageEnglish (US)
Pages (from-to)15-24,382-383
JournalProgress in Brain Research
Volume157
DOIs
StatePublished - Jan 1 2006

Keywords

  • BDNF
  • TrkB
  • conditional knockouts
  • neurotrophins
  • synaptogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

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