Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype

for the Hepatitis B Research Network

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background & Aims: Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network. Methods: The HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America. Results: Half of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range. Conclusions: The HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America.

Original languageEnglish (US)
Pages (from-to)183-192
Number of pages10
JournalClinical Gastroenterology and Hepatology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2015

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North America
Hepatitis B
Hepatitis B virus
Hepatitis
Genotype
Chronic Hepatitis B
Research
Virus Diseases
Canada
Therapeutic Human Experimentation
Translational Medical Research
Hepatitis B e Antigens
Health Policy
Alanine Transaminase
Antiviral Agents
Hepatocellular Carcinoma
Reference Values
Fibrosis
Research Personnel
DNA

Keywords

  • ALT
  • Chronic hepatitis B virus infection
  • HBeAg
  • USA

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype. / for the Hepatitis B Research Network.

In: Clinical Gastroenterology and Hepatology, Vol. 13, No. 1, 01.01.2015, p. 183-192.

Research output: Contribution to journalArticle

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abstract = "Background & Aims: Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network. Methods: The HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America. Results: Half of the subjects in the HBRN are men, and the median age is 42 years; 72{\%} are Asian, 15{\%} are black, and 11{\%} are white; with 82{\%} born outside of North America. The most common HBV genotype was B (39{\%}); 74{\%} of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68{\%} of male subjects and 67{\%} of female subjects had alanine aminotransferase levels higher than the normal range. Conclusions: The HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America.",
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AU - Ghany, Marc G.

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AU - Belle, Steven H.

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AU - Terrault, Norah A.

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AU - Kim, W. Ray

AU - Fried, Michael W.

AU - Sterling, Richard K.

AU - Di Bisceglie, Adrian M.

AU - Han, Steven Huy B

AU - Ganova-Raeva, Lilia Milkova

AU - Chang, Kyong Mi

AU - Lok, Anna Suk Fong

AU - Chung, Raymond T.

AU - Roberts, Lewis R.

AU - Smith, Coleman I.

AU - Lisker-Melman, Mauricio

AU - Wong, David K.

AU - Juan, Joshua

AU - Feld, Jordan

AU - Yim, Colina

AU - Heathcoate, Jenny

AU - Lee, William M.

AU - Do, Son

AU - Tran, Tram T.

AU - Khalili, Mandana

AU - Cooper, Stewart L.

AU - Fontana, Robert J.

AU - Tsai, Naoky

AU - Patel, Keyur

AU - Evon, Donna

AU - Carithers, Robert C.

AU - Kowdley, Kris V.

AU - Wang, Chia C.

AU - Liang, T. Jake

AU - Park, Jang June

AU - Wahed, Abdus

AU - Kleiner, David

AU - Afdhal, Nezam

AU - Javaid, Asad

AU - Niu, Jianghe

AU - Han, Johanna

AU - Nasser, Imad

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KW - Chronic hepatitis B virus infection

KW - HBeAg

KW - USA

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