Characterization of a novel MICA allele, MICA*047

Y. Zhang, A. M. Lázaro, F. Mirbaha, B. Lavingia, R. Vorhaben, P. Stastny

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We report the identification of a novel MICA allele, MICA*047. It was initially detected because of an unusual hybridization pattern with sequence-specific oligonucleotides (SSOP) in a normal subject of Caucasian origin. Cloning and sequencing of both strands, and comparison of the sequence with previously defined MICA alleles, revealed that the new allele is similar to MICA*041 except for one nucleotide substitution at position 811 (C→G). It appears that this new allele could have been generated by an interallelic sequence exchange between MICA*011 and MICA*0411.

Original languageEnglish (US)
Pages (from-to)308-310
Number of pages3
JournalTissue Antigens
Volume59
Issue number4
DOIs
StatePublished - 2002

Keywords

  • MICA*047
  • Polymorphism
  • Sequence-based typing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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