Abstract
Background: The reason for the variability in degree of atherosclerosis in Tangier disease remains poorly understood. Results: Tangier fibroblasts with different molecular defects display marked phenotypic variability. Conclusion: Complete ABCA1 deficiency is associated with various potentially atherogenic effects and is compensated for by marked oxysterol-mediated down-regulation of cholesterol biosynthesis. Significance: Elucidation of the link between the degree of ABCA1 deficiency and the in vivo phenotype.
Original language | English (US) |
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Pages (from-to) | 36936-36947 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 52 |
DOIs | |
State | Published - Dec 27 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology