Characterization of clinical response in patients with vitiligo undergoing autologous epidermal punch grafting

Hattie Jill Feetham, Joanna L. Chan, Amit G. Pandya

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

BACKGROUND: Punch grafting is a well-established treatment for vitiligo, but predictive factors for outcomes are not well established. OBJECTIVE: To determine the characteristics of responses to punch grafting performed in patients with vitiligo. METHODS AND MATERIALS: Retrospective, single-center chart review. Response rates were assessed using photographs taken before and after grafting using a 1.5-mm punch instrument. Effectiveness of repigmentation was assessed using the following scale: worse, no improvement, 0% to 25% improvement, 25% to 50% improvement, 50% to 75% improvement, and 75% to 100% improvement. Repigmentation rates were correlated with patient demographics. RESULTS: Thirty-seven charts were reviewed, from which data were available from 30 patients. The total number grafts was 606 in 44 transplanted areas; 87% (530/606) of the transplants survived, and 26 of the 30 (87%) patients achieved some degree of repigmentation. Patients younger than 20 achieved the greatest average improvement in repigmentation (mean 61%), whereas those aged 60 and older showed the least improvement (mean 38%). Punch grafting of the neck and trunk achieved the greatest repigmentation, with 65% and 63% average improvement, respectively. Acral sites and skin overlying joints improved the least. CONCLUSION: Punch grafting is successful in most patients with vitiligo, with an 87% graft survival rate, but the rates of repigmentation vary depending on clinical characteristics.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalDermatologic Surgery
Volume38
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Vitiligo
Transplants
Graft Survival
Neck
Survival Rate
Extremities
Joints
Demography
Skin

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Characterization of clinical response in patients with vitiligo undergoing autologous epidermal punch grafting. / Feetham, Hattie Jill; Chan, Joanna L.; Pandya, Amit G.

In: Dermatologic Surgery, Vol. 38, No. 1, 01.2012, p. 14-19.

Research output: Contribution to journalArticle

@article{ffbe66547ead435b8d927a6ffece66ff,
title = "Characterization of clinical response in patients with vitiligo undergoing autologous epidermal punch grafting",
abstract = "BACKGROUND: Punch grafting is a well-established treatment for vitiligo, but predictive factors for outcomes are not well established. OBJECTIVE: To determine the characteristics of responses to punch grafting performed in patients with vitiligo. METHODS AND MATERIALS: Retrospective, single-center chart review. Response rates were assessed using photographs taken before and after grafting using a 1.5-mm punch instrument. Effectiveness of repigmentation was assessed using the following scale: worse, no improvement, 0{\%} to 25{\%} improvement, 25{\%} to 50{\%} improvement, 50{\%} to 75{\%} improvement, and 75{\%} to 100{\%} improvement. Repigmentation rates were correlated with patient demographics. RESULTS: Thirty-seven charts were reviewed, from which data were available from 30 patients. The total number grafts was 606 in 44 transplanted areas; 87{\%} (530/606) of the transplants survived, and 26 of the 30 (87{\%}) patients achieved some degree of repigmentation. Patients younger than 20 achieved the greatest average improvement in repigmentation (mean 61{\%}), whereas those aged 60 and older showed the least improvement (mean 38{\%}). Punch grafting of the neck and trunk achieved the greatest repigmentation, with 65{\%} and 63{\%} average improvement, respectively. Acral sites and skin overlying joints improved the least. CONCLUSION: Punch grafting is successful in most patients with vitiligo, with an 87{\%} graft survival rate, but the rates of repigmentation vary depending on clinical characteristics.",
author = "Feetham, {Hattie Jill} and Chan, {Joanna L.} and Pandya, {Amit G.}",
year = "2012",
month = "1",
doi = "10.1111/j.1524-4725.2011.02171.x",
language = "English (US)",
volume = "38",
pages = "14--19",
journal = "Dermatologic Surgery",
issn = "1076-0512",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Characterization of clinical response in patients with vitiligo undergoing autologous epidermal punch grafting

AU - Feetham, Hattie Jill

AU - Chan, Joanna L.

AU - Pandya, Amit G.

PY - 2012/1

Y1 - 2012/1

N2 - BACKGROUND: Punch grafting is a well-established treatment for vitiligo, but predictive factors for outcomes are not well established. OBJECTIVE: To determine the characteristics of responses to punch grafting performed in patients with vitiligo. METHODS AND MATERIALS: Retrospective, single-center chart review. Response rates were assessed using photographs taken before and after grafting using a 1.5-mm punch instrument. Effectiveness of repigmentation was assessed using the following scale: worse, no improvement, 0% to 25% improvement, 25% to 50% improvement, 50% to 75% improvement, and 75% to 100% improvement. Repigmentation rates were correlated with patient demographics. RESULTS: Thirty-seven charts were reviewed, from which data were available from 30 patients. The total number grafts was 606 in 44 transplanted areas; 87% (530/606) of the transplants survived, and 26 of the 30 (87%) patients achieved some degree of repigmentation. Patients younger than 20 achieved the greatest average improvement in repigmentation (mean 61%), whereas those aged 60 and older showed the least improvement (mean 38%). Punch grafting of the neck and trunk achieved the greatest repigmentation, with 65% and 63% average improvement, respectively. Acral sites and skin overlying joints improved the least. CONCLUSION: Punch grafting is successful in most patients with vitiligo, with an 87% graft survival rate, but the rates of repigmentation vary depending on clinical characteristics.

AB - BACKGROUND: Punch grafting is a well-established treatment for vitiligo, but predictive factors for outcomes are not well established. OBJECTIVE: To determine the characteristics of responses to punch grafting performed in patients with vitiligo. METHODS AND MATERIALS: Retrospective, single-center chart review. Response rates were assessed using photographs taken before and after grafting using a 1.5-mm punch instrument. Effectiveness of repigmentation was assessed using the following scale: worse, no improvement, 0% to 25% improvement, 25% to 50% improvement, 50% to 75% improvement, and 75% to 100% improvement. Repigmentation rates were correlated with patient demographics. RESULTS: Thirty-seven charts were reviewed, from which data were available from 30 patients. The total number grafts was 606 in 44 transplanted areas; 87% (530/606) of the transplants survived, and 26 of the 30 (87%) patients achieved some degree of repigmentation. Patients younger than 20 achieved the greatest average improvement in repigmentation (mean 61%), whereas those aged 60 and older showed the least improvement (mean 38%). Punch grafting of the neck and trunk achieved the greatest repigmentation, with 65% and 63% average improvement, respectively. Acral sites and skin overlying joints improved the least. CONCLUSION: Punch grafting is successful in most patients with vitiligo, with an 87% graft survival rate, but the rates of repigmentation vary depending on clinical characteristics.

UR - http://www.scopus.com/inward/record.url?scp=84855543355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855543355&partnerID=8YFLogxK

U2 - 10.1111/j.1524-4725.2011.02171.x

DO - 10.1111/j.1524-4725.2011.02171.x

M3 - Article

VL - 38

SP - 14

EP - 19

JO - Dermatologic Surgery

JF - Dermatologic Surgery

SN - 1076-0512

IS - 1

ER -