TY - JOUR
T1 - Characterization of incidetally identified minut clonal B-lymphocyte populations in peripheral blood and bone marrow
AU - Chen, Weina
AU - Asplund, Sheryl L.
AU - McKenna, Robert W.
AU - Kroft, Steven H.
PY - 2004/10
Y1 - 2004/10
N2 - We describe 69 patients in whom small clonal B-cell populations were detected incidentally in blood and bone marrow samples by flow cytometric studies. In 20 patients (29%), non-Hodgkin lymphoma (NHL) subsequently was diagnosed 0 to 40 months (median, 0.1 month) from initial flow cytometric studies. In 49 patients (71%), there was no evidence of NHL after 0.5 to 72 months (median, 16 months). Patients without overt NHL had a higher absolute WBC count than patients with NHL (2,260/μL vs 1,470/μL [2.26 vs 1.47 × 109/L]; P < .01). Otherwise, there were no clinical or hematologic differences between the 2 groups. We identified 70 clonal populations in the 69 patients, ranging from 0.05% to 4.5% (median, 1.28%) of events. The mean percentage of clonal B cells was similar for the 2 groups. The populations were CD5-/CD10- in 34 cases; CD5+, chronic lymphocytic leukemia-like in 19; CD5+, indeterminate in 9; CD10+ in 3; hairy cell leukemia-like in 3; and CD5+, mantle cell lymphoma-like in 2. There were no immunophenotypic differences in patients with and without overt NHL.
AB - We describe 69 patients in whom small clonal B-cell populations were detected incidentally in blood and bone marrow samples by flow cytometric studies. In 20 patients (29%), non-Hodgkin lymphoma (NHL) subsequently was diagnosed 0 to 40 months (median, 0.1 month) from initial flow cytometric studies. In 49 patients (71%), there was no evidence of NHL after 0.5 to 72 months (median, 16 months). Patients without overt NHL had a higher absolute WBC count than patients with NHL (2,260/μL vs 1,470/μL [2.26 vs 1.47 × 109/L]; P < .01). Otherwise, there were no clinical or hematologic differences between the 2 groups. We identified 70 clonal populations in the 69 patients, ranging from 0.05% to 4.5% (median, 1.28%) of events. The mean percentage of clonal B cells was similar for the 2 groups. The populations were CD5-/CD10- in 34 cases; CD5+, chronic lymphocytic leukemia-like in 19; CD5+, indeterminate in 9; CD10+ in 3; hairy cell leukemia-like in 3; and CD5+, mantle cell lymphoma-like in 2. There were no immunophenotypic differences in patients with and without overt NHL.
KW - Chronic lymphocytic leukemia
KW - Flow cytometry
KW - Incidental
KW - Marginal zone
KW - Small B-cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=85047693469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047693469&partnerID=8YFLogxK
U2 - 10.1309/6UGDU03VVD0L98LQ
DO - 10.1309/6UGDU03VVD0L98LQ
M3 - Article
C2 - 15487458
AN - SCOPUS:85047693469
SN - 0002-9173
VL - 122
SP - 588
EP - 595
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 4
ER -