Characterization of incidetally identified minut clonal B-lymphocyte populations in peripheral blood and bone marrow

Weina Chen, Sheryl L. Asplund, Robert W. McKenna, Steven H. Kroft

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We describe 69 patients in whom small clonal B-cell populations were detected incidentally in blood and bone marrow samples by flow cytometric studies. In 20 patients (29%), non-Hodgkin lymphoma (NHL) subsequently was diagnosed 0 to 40 months (median, 0.1 month) from initial flow cytometric studies. In 49 patients (71%), there was no evidence of NHL after 0.5 to 72 months (median, 16 months). Patients without overt NHL had a higher absolute WBC count than patients with NHL (2,260/μL vs 1,470/μL [2.26 vs 1.47 × 109/L]; P < .01). Otherwise, there were no clinical or hematologic differences between the 2 groups. We identified 70 clonal populations in the 69 patients, ranging from 0.05% to 4.5% (median, 1.28%) of events. The mean percentage of clonal B cells was similar for the 2 groups. The populations were CD5-/CD10- in 34 cases; CD5+, chronic lymphocytic leukemia-like in 19; CD5+, indeterminate in 9; CD10+ in 3; hairy cell leukemia-like in 3; and CD5+, mantle cell lymphoma-like in 2. There were no immunophenotypic differences in patients with and without overt NHL.

Original languageEnglish (US)
Pages (from-to)588-595
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume122
Issue number4
DOIs
StatePublished - Jan 1 2004

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B-Lymphocytes
Bone Marrow
Non-Hodgkin's Lymphoma
Population
Mantle-Cell Lymphoma
Hairy Cell Leukemia
B-Cell Chronic Lymphocytic Leukemia

Keywords

  • Chronic lymphocytic leukemia
  • Flow cytometry
  • Incidental
  • Marginal zone
  • Small B-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Characterization of incidetally identified minut clonal B-lymphocyte populations in peripheral blood and bone marrow. / Chen, Weina; Asplund, Sheryl L.; McKenna, Robert W.; Kroft, Steven H.

In: American Journal of Clinical Pathology, Vol. 122, No. 4, 01.01.2004, p. 588-595.

Research output: Contribution to journalArticle

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