Characterization of individual ultrasound microbubble dynamics with a light-scattering system

Mark J. Hsu; Mohammad Eghtedari; Andrew P. Goodwin; David J. Hall; Robert F. Mattrey; Sadik C. Esener

doi:10.1117/1.3583575

Characterization of individual ultrasound microbubble dynamics with a light-scattering system

Mark J. Hsu, Mohammad Eghtedari, Andrew P. Goodwin, David J. Hall, Robert F. Mattrey, Sadik C. Esener

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Ultrasound microbubbles are contrast agents used for diagnostic ultrasound imaging and as carriers for noninvasive payload delivery. Understanding the acoustic properties of individual microbubble formulations is important for optimizing the ultrasound imaging parameters for improved image contrast and efficient payload delivery. We report here a practical and simple optical tool for direct real-time characterization of ultrasound contrast microbubble dynamics based on light scattering. Fourier transforms of raw linear and nonlinear acoustic oscillations, and microbubble cavitations are directly recorded. Further, the power of this tool is demonstrated by comparing clinically relevant microbubble cycle-to-cycle dynamics and their corresponding Fourier transforms.

Original language	English (US)
Article number	067002
Journal	Journal of biomedical optics
Volume	16
Issue number	6
DOIs	https://doi.org/10.1117/1.3583575
State	Published - Jun 2011

Keywords

acousto-optics
medical imaging
ultrasonics

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomedical Engineering
Biomaterials

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10.1117/1.3583575

Cite this

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abstract = "Ultrasound microbubbles are contrast agents used for diagnostic ultrasound imaging and as carriers for noninvasive payload delivery. Understanding the acoustic properties of individual microbubble formulations is important for optimizing the ultrasound imaging parameters for improved image contrast and efficient payload delivery. We report here a practical and simple optical tool for direct real-time characterization of ultrasound contrast microbubble dynamics based on light scattering. Fourier transforms of raw linear and nonlinear acoustic oscillations, and microbubble cavitations are directly recorded. Further, the power of this tool is demonstrated by comparing clinically relevant microbubble cycle-to-cycle dynamics and their corresponding Fourier transforms.",

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note = "Funding Information: Work described in this paper was supported in part by NIH Grant No. T32EB005970, RSNA research resident award RR0917, and DOD Award W81XWH-07–1-0125.",

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AU - Hall, David J.

AU - Mattrey, Robert F.

AU - Esener, Sadik C.

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AB - Ultrasound microbubbles are contrast agents used for diagnostic ultrasound imaging and as carriers for noninvasive payload delivery. Understanding the acoustic properties of individual microbubble formulations is important for optimizing the ultrasound imaging parameters for improved image contrast and efficient payload delivery. We report here a practical and simple optical tool for direct real-time characterization of ultrasound contrast microbubble dynamics based on light scattering. Fourier transforms of raw linear and nonlinear acoustic oscillations, and microbubble cavitations are directly recorded. Further, the power of this tool is demonstrated by comparing clinically relevant microbubble cycle-to-cycle dynamics and their corresponding Fourier transforms.

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Characterization of individual ultrasound microbubble dynamics with a light-scattering system

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Keywords

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