Characterization of methadone receptor subtypes present in human brain and lung tissues

Rhoda Maneckjee, John D. Minna

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In addition to their use in pain control, opioids can function as regulators of tumor cell growth. We have found that the therapeutic opioid, methadone, significantly inhibits the in vitro and in vivo growth of human lung cancer cells, and this effect appears to be mediated by specific, high affinity, non-conventional opioid binding sites. The present study indicates the existence of multiple subtypes of binding sites mediating the peripheral and central nervous system actions of this drug. Pharmacological and biochemical characterizations of the methadone binding sites expressed in human brain and normal lung tissues indicate that these sites are distinct from each other and from other opioid receptor types present on human and rat brain membranes, as well as those expressed in human lung cancer cells. The identification of distinct methadone receptor types in the different tissues could lead to the development of more selective and less toxic drugs targeted toward the tumor cells.

Original languageEnglish (US)
Pages (from-to)333-338
Number of pages6
JournalLife Sciences
Volume61
Issue number22
StatePublished - Oct 24 1997

Fingerprint

Methadone
Opioid Analgesics
Brain
Binding Sites
Cells
Tissue
Lung
Tumors
Lung Neoplasms
Poisons
Cell growth
Neurology
Opioid Receptors
Central Nervous System Agents
Pharmaceutical Preparations
Rats
Peripheral Nervous System
Growth
Membranes
Neoplasms

Keywords

  • Brain
  • Lung cancer cells
  • Methadone receptors
  • Radioligand binding

ASJC Scopus subject areas

  • Pharmacology

Cite this

Characterization of methadone receptor subtypes present in human brain and lung tissues. / Maneckjee, Rhoda; Minna, John D.

In: Life Sciences, Vol. 61, No. 22, 24.10.1997, p. 333-338.

Research output: Contribution to journalArticle

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