Characterization of methadone receptor subtypes present in human brain and lung tissues

Rhoda Maneckjee, John D. Minna

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

In addition to their use in pain control, opioids can function as regulators of tumor cell growth. We have found that the therapeutic opioid, methadone, significantly inhibits the in vitro and in vivo growth of human lung cancer cells, and this effect appears to be mediated by specific, high affinity, non-conventional opioid binding sites. The present study indicates the existence of multiple subtypes of binding sites mediating the peripheral and central nervous system actions of this drug. Pharmacological and biochemical characterizations of the methadone binding sites expressed in human brain and normal lung tissues indicate that these sites are distinct from each other and from other opioid receptor types present on human and rat brain membranes, as well as those expressed in human lung cancer cells. The identification of distinct methadone receptor types in the different tissues could lead to the development of more selective and less toxic drugs targeted toward the tumor cells.

Original languageEnglish (US)
Pages (from-to)PL333-PL338
JournalLife Sciences
Volume61
Issue number22
StatePublished - Oct 24 1997

Keywords

  • Brain
  • Lung cancer cells
  • Methadone receptors
  • Radioligand binding

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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