Characterization of polymer coated magnetic nanoparticles for targeted treatment of cancer

Sivaniaravindapriya Nattama, Maham Rahimi, Aniket S. Wadajkar, Bhanuprasanth Koppolu, Jennifer Hua, Fiemu Nwariaku, Kytai T. Nguyen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

The objective of this project is to develop and characterize a targeted drug delivery vehicle capable of the controlled release of chemotherapy to treat malignant tumors. Our construct consists of a magnetic core with a thermosensitive polymer (N-isopropylacrylamide, NIPA) shell. The advantage of this system is that a magnetic field can be used for targeting the construct as well as to induce heat for hyperthermia treatment. Furthermore, the drug can be loaded into the NIPA layer and released when the temperature reaches its lower critical solution temperature (LCST). Drug release studies were used to characterize the thermoresponsive properties of the construct. Cellular uptake and cytotoxicity studies were also performed to determine in vitro behavior. Our NIPA-magnetic nanoparticle presents a unique and effective method of treating many cancers while reducing the deleterious effects associated with traditional drug delivery methods.

Original languageEnglish (US)
Title of host publication2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS
Pages35-38
Number of pages4
DOIs
StatePublished - Dec 1 2007
Event2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS - Richardson, TX, United States
Duration: Nov 11 2007Nov 12 2007

Publication series

Name2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS

Other

Other2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS
CountryUnited States
CityRichardson, TX
Period11/11/0711/12/07

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Nattama, S., Rahimi, M., Wadajkar, A. S., Koppolu, B., Hua, J., Nwariaku, F., & Nguyen, K. T. (2007). Characterization of polymer coated magnetic nanoparticles for targeted treatment of cancer. In 2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS (pp. 35-38). [4454167] (2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS). https://doi.org/10.1109/EMBSW.2007.4454167