TY - JOUR
T1 - Characterization of retinal architecture in Parkinson's disease
AU - Chorostecki, Jessica
AU - Seraji-Bozorgzad, Navid
AU - Shah, Aashka
AU - Bao, Fen
AU - Bao, Ginny
AU - George, Edwin
AU - Gorden, Veronica
AU - Caon, Christina
AU - Frohman, Elliot
AU - Tariq Bhatti, M.
AU - Khan, Omar
N1 - Funding Information:
The study was supported by the Sastry Family Foundation , the Goldye Nelson Award in Neurosciences. Dr. Seraji-Bozorgzad is supported by the Wayne State University Neuroscience Program.
Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/8/15
Y1 - 2015/8/15
N2 - Background Parkinson's disease (PD) is a neurodegenerative disorder associated with dopaminergic cell loss and α-synuclein aggregation in Lewy bodies, which has been demonstrated in the retina. Methods We performed a spectral-domain optical coherence tomography (OCT) study in patients with PD and healthy controls to measure the peripapillary retinal nerve fiber layer thickness and macular volume. Intra-retinal segmentation was performed to measure the volume of the retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL), and outer nuclear (ONL) layers. Analysis was carried out blinded to the clinical status of study participants. Results 101 PD and 46 healthy control eyes were included in the study. In PD patients, peripapillary retinal nerve fiber layer was not significantly thinner (96.95 μm vs 94.42 μm, p = 0.08) but macular volume was (8.58 mm3 vs 8.33 mm3, p = 0.0002). Intra-retinal segmentation showed that PD subjects have reduced GCL, IPL, INL and ONL volumes. In contrast, the OPL volume was significantly increased (0.81 mm3 vs 0.78 mm3 p = 0.0214). Conclusions Thickening of the OPL is a novel finding which may correspond to the localization of α-synuclein in the OPL of PD patients. We hypothesize that the enlargement of the OPL may represent a potential biomarker of α-synuclein aggregation in PD. This may have significant clinical implications.
AB - Background Parkinson's disease (PD) is a neurodegenerative disorder associated with dopaminergic cell loss and α-synuclein aggregation in Lewy bodies, which has been demonstrated in the retina. Methods We performed a spectral-domain optical coherence tomography (OCT) study in patients with PD and healthy controls to measure the peripapillary retinal nerve fiber layer thickness and macular volume. Intra-retinal segmentation was performed to measure the volume of the retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL), and outer nuclear (ONL) layers. Analysis was carried out blinded to the clinical status of study participants. Results 101 PD and 46 healthy control eyes were included in the study. In PD patients, peripapillary retinal nerve fiber layer was not significantly thinner (96.95 μm vs 94.42 μm, p = 0.08) but macular volume was (8.58 mm3 vs 8.33 mm3, p = 0.0002). Intra-retinal segmentation showed that PD subjects have reduced GCL, IPL, INL and ONL volumes. In contrast, the OPL volume was significantly increased (0.81 mm3 vs 0.78 mm3 p = 0.0214). Conclusions Thickening of the OPL is a novel finding which may correspond to the localization of α-synuclein in the OPL of PD patients. We hypothesize that the enlargement of the OPL may represent a potential biomarker of α-synuclein aggregation in PD. This may have significant clinical implications.
KW - Alpha-synuclein
KW - Dopamine
KW - Optical coherence tomography
KW - Parkinson's disease
KW - Retina
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U2 - 10.1016/j.jns.2015.05.007
DO - 10.1016/j.jns.2015.05.007
M3 - Article
C2 - 26071887
AN - SCOPUS:84937526911
SN - 0022-510X
VL - 355
SP - 44
EP - 48
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -