Characterization of the Relationship Between Intracranial Pressure and Electroencephalographic Monitoring in Burst-Suppressed Patients

Mark Connolly, Paul Vespa, Nader Pouratian, Nestor R. Gonzalez, Xiao Hu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The objective of this study is to characterize the relationship between ICP and EEG Methods: Simultaneous ICP and EEG data were obtained from burst-suppressed patients and segmented by EEG bursts. Segments were categorized as increasing/decreasing and peak/valley to investigate relationship between ICP changes and EEG burst duration. A generalized ICP response was obtained by averaging all segments time-aligned at burst onsets. A vasodilatation index (VDI) was derived from the ICP pulse waveform and calculated on a sliding interval to investigate cerebrovascular changes post-burst. Results: Data from two patients contained 309 bursts. 246 ICP segments initially increased, of which 154 peaked. 63 ICP segments decreased, and zero reached a valley. The change in ICP (0.54 ± 0.85 mmHg) was significantly correlated with the burst duration (p < 0.001). Characterization of the ICP segments showed a peak at 8.1 s and a return to baseline at 14.7 s. The VDI for increasing segments was significantly elevated (median 0.56, IQR 0.31, p < 0.001) and correlated with burst duration (p < 0.001). Conclusions: Changes in the ICP and pulse waveform shape after EEG burst suggest that these signals can be related within the context of neurovascular coupling. Significance: Existence of a physiological relationship between ICP and EEG may allow the study of neurovascular coupling in acute brain injury patients.

Original languageEnglish (US)
Pages (from-to)212-220
Number of pages9
JournalNeurocritical Care
Volume22
Issue number2
DOIs
StatePublished - Apr 2015
Externally publishedYes

Keywords

  • Acute brain injury
  • Electroencephalogram
  • Intracranial pressure
  • Multi-modality monitoring
  • Neurovascular coupling

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

Fingerprint

Dive into the research topics of 'Characterization of the Relationship Between Intracranial Pressure and Electroencephalographic Monitoring in Burst-Suppressed Patients'. Together they form a unique fingerprint.

Cite this