Characterization of two class I genes from the H2-M region: Evidence for a new subfamily

S. Rao Arepalli, Elsy P. Jones, T. Kevin Howcroft, Irene Carlo, Chyung Ru Wang, Kirsten Fischer Lindahl, Dinah S. Singer, Stuart Rudikoff

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We cloned, sequenced, and mapped two divergent major histocompatibility class Ib genes from BALB/c mice. M9(d) and M10(d) both have the potential to encode full-length class I molecules, but transcripts were not readily detectable. M9 is 86% similar to M1 in its nucleotide sequence and maps next to it on YAC clones. M9 is only 64% similar to M10 and 60% to H2-K(k). Probes from M10 define a new subfamily of eight class I genes in C3H mice; five cluster directly distal to H2-T1, and three are located between M9-1-7-8 and M6-4-5 in the H2-M region.

Original languageEnglish (US)
Pages (from-to)264-271
Number of pages8
JournalImmunogenetics
Volume47
Issue number3
DOIs
StatePublished - 1998

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Keywords

  • Distal Mhc
  • Divergent class Ib gene
  • H2-M region
  • M1 subfamily
  • M10 subfamily

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Arepalli, S. R., Jones, E. P., Howcroft, T. K., Carlo, I., Wang, C. R., Lindahl, K. F., Singer, D. S., & Rudikoff, S. (1998). Characterization of two class I genes from the H2-M region: Evidence for a new subfamily. Immunogenetics, 47(3), 264-271. https://doi.org/10.1007/s002510050356