Characterizing brain oxygen metabolism in patients with multiple sclerosis with T2-relaxation-under-spin-tagging MRI

Yulin Ge, Zhongwei Zhang, Hanzhang Lu, Lin Tang, Hina Jaggi, Joseph Herbert, James S. Babb, Henry Rusinek, Robert I. Grossman

Research output: Contribution to journalArticle

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Abstract

In this study, venous oxygen saturation and oxygen metabolic changes in multiple sclerosis (MS) patients were assessed using a recently developed T2-relaxation-under-spin-tagging (TRUST) magnetic resonance imaging (MRI), which measures the superior sagittal venous sinus blood oxygenation (Yv) and cerebral metabolic rate of oxygen (CMRO 2), an index of global oxygen consumption. Thirty patients with relapsing-remitting MS and 30 age-matched healthy controls were studied using TRUST at 3 T MR. The mean expanded disability status scale (EDSS) of the patients was 2.3 (range, 0 to 5.5). We found significantly increased Yv (P<0.0001) and decreased CMRO 2 (P=0.003) in MS patients (mean±s.d.: 65.9%±5.1% and 138.8±35.4 mol per 100 g per minute) as compared with healthy control subjects (60.2%±4.0% and 180.2±24.8 mol per 100 g per minute, respectively), implying decrease of oxygen consumption in MS. There was a significant positive correlation between Yv and EDSS and between Yv and lesion load in MS patients (n=30); on the contrary, there was a significant negative correlation between CMRO 2 and EDSS and between CMRO 2 and lesion load (n=12). There was no correlation between Yv and brain atrophy measures. This study showed preliminary evidence of the potential utility of TRUST in global oxygen metabolism. Our results of significant underutilization of oxygen in MS raise important questions regarding mitochondrial respiratory dysfunction and neurodegeneration of the disease.

Original languageEnglish (US)
Pages (from-to)403-412
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number3
DOIs
StatePublished - Mar 2012

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Multiple Sclerosis
Magnetic Resonance Imaging
Oxygen
Brain
Oxygen Consumption
Superior Sagittal Sinus
Relapsing-Remitting Multiple Sclerosis
Atrophy
Healthy Volunteers

Keywords

  • MRI
  • multiple sclerosis
  • neurodegeneration
  • nitric oxide
  • oxygen metabolism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Characterizing brain oxygen metabolism in patients with multiple sclerosis with T2-relaxation-under-spin-tagging MRI. / Ge, Yulin; Zhang, Zhongwei; Lu, Hanzhang; Tang, Lin; Jaggi, Hina; Herbert, Joseph; Babb, James S.; Rusinek, Henry; Grossman, Robert I.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 32, No. 3, 03.2012, p. 403-412.

Research output: Contribution to journalArticle

Ge, Yulin ; Zhang, Zhongwei ; Lu, Hanzhang ; Tang, Lin ; Jaggi, Hina ; Herbert, Joseph ; Babb, James S. ; Rusinek, Henry ; Grossman, Robert I. / Characterizing brain oxygen metabolism in patients with multiple sclerosis with T2-relaxation-under-spin-tagging MRI. In: Journal of Cerebral Blood Flow and Metabolism. 2012 ; Vol. 32, No. 3. pp. 403-412.
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