Characterizing cortical neuron injury with fluoro-jade labeling after a neurotoxic regimen of methamphetamine

Amelia J. Eisch, Larry C. Schmued, John F. Marshall

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

We used Fluoro-Jade, a recently-developed fluorescent indicator of neuronal damage, to identify neurons injured 1-21 days after repeated injections of methamphetamine (m-AMPH) or saline. The m-AMPH-treated rats showed Fluoro-Jade positive neurons in parietal cortex (layers III and IV) and had less striatal tyrosine hydroxylase immunoreactivity than did saline- injected controls. Fluoro-Jade positive neurons were greatest in number 3 days post-treatment; some fluorescent neurons displayed bud-like surface protrusions. These observations support the hypothesis that certain neocortical neurons degenerate after m-AMPH.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalSynapse
Volume30
Issue number3
DOIs
Publication statusPublished - Nov 1998

    Fingerprint

Keywords

  • Amphetamine
  • Apoptosis
  • Degeneration
  • Dopamine
  • Drugs of abuse
  • Somatosensory cortex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pharmacology

Cite this