Characterizing retinal structure injury in African-Americans with multiple sclerosis

Navid Seraji-Bozorgzad, Sheridan Reed, Fen Bao, Carla Santiago, Alexandros Tselis, Evanthia Bernitsas, Christina Caon, Elliot Frohman, M. Tariq Bhatti, Bruce A C Cree, Omar Khan

Research output: Contribution to journalArticle

6 Scopus citations


To examine retinal structure injury in African-Americans (AA) with Multiple Sclerosis (MS) compared to Caucasians (CA) with MS, we used spectral domain optical-coherence tomography (OCT) in this cross sectional study. The peripapillary retinal nerve fiber layer (pRNFL) and macular volume of 234 MS patients (149 CA; 85 AA) and 74 healthy controls (60 CA; 17 AA) were measured. Intra-retinal segmentation was performed to obtain retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL), outer nuclear (ONL), retinal pigment epithelium (RPE), and photoreceptor (PR) layer volumes. Study was approved by IRB, and informed consent obtained from all participants. We found that pRNFL was thicker in AA v. CA healthy controls (100.9 vs 97.00 μm, p=0.004). Compared to HC, MS patients demonstrated thinner pRNFL (p3, p=0.0001), RNFL (0.73 vs 0.79 mm3, p=0.0001), and GCL (0.94 vs 0.98 mm3, p=0.007) than CAMS patients. Sub-analysis of patients without history of AON showed thinner pRNFL (88.9 vs 93.1 μm) and TMV (8.2 vs. 8.5 mm3, p

Original languageEnglish (US)
Pages (from-to)16-20
Number of pages5
JournalMultiple Sclerosis and Related Disorders
StatePublished - May 1 2016


  • African-American
  • Health disparity
  • Multiple sclerosis
  • Optical coherence tomography
  • Retinal structure injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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  • Cite this

    Seraji-Bozorgzad, N., Reed, S., Bao, F., Santiago, C., Tselis, A., Bernitsas, E., Caon, C., Frohman, E., Bhatti, M. T., Cree, B. A. C., & Khan, O. (2016). Characterizing retinal structure injury in African-Americans with multiple sclerosis. Multiple Sclerosis and Related Disorders, 7, 16-20.