Characterizing solid renal neoplasms with MRI in adults

Brian C. Allen, Philippe Tirman, M. Jennings Clingan, Julia Manny, Andrew J. Del Gaizo, John R. Leyendecker

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Until recently, most solid renal neoplasms without macroscopic fat were presumed to represent renal cell carcinoma and were indiscriminately treated with nephrectomy. Expanding surgical options and ablative technologies, a growing acceptance of renal mass biopsy, the advent of targeted molecular agents, and advances in our understanding of tumor biology have challenged the wisdom of this approach and are ushering in a potential new era in which therapy is linked to histologic subtype and cytogenetics. This approach mandates evolution of our diagnostic algorithm beyond the distinction between solid and cystic and enhancing and nonenhancing. Computed tomography (CT) has traditionally been the imaging technique of choice for evaluating potential solid renal tumors, in large part due to its widespread availability, high spatial resolution, calcium discrimination, and multiphase, enhanced imaging capabilities. For the most part, however, CT is limited to characterization based upon the attenuation and enhancement characteristics of a lesion and necessitates exposure of patients to ionizing radiation. For these latter reasons, multiparametric magnetic resonance imaging (MRI) is being increasingly used to characterize solid renal masses. The purpose of this manuscript is to review our imaging approach to solid renal masses in adults utilizing MRI with an emphasis on a multiparametric approach augmented by clinical data.

Original languageEnglish (US)
Pages (from-to)358-387
Number of pages30
JournalAbdominal Imaging
Volume39
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Kidney Neoplasms
Magnetic Resonance Imaging
Kidney
Tomography
Ionizing Radiation
Nephrectomy
Renal Cell Carcinoma
Cytogenetics
Neoplasms
Fats
Calcium
Technology
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology
  • Urology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Allen, B. C., Tirman, P., Clingan, M. J., Manny, J., Del Gaizo, A. J., & Leyendecker, J. R. (2014). Characterizing solid renal neoplasms with MRI in adults. Abdominal Imaging, 39(2), 358-387. https://doi.org/10.1007/s00261-014-0074-4

Characterizing solid renal neoplasms with MRI in adults. / Allen, Brian C.; Tirman, Philippe; Clingan, M. Jennings; Manny, Julia; Del Gaizo, Andrew J.; Leyendecker, John R.

In: Abdominal Imaging, Vol. 39, No. 2, 01.01.2014, p. 358-387.

Research output: Contribution to journalReview article

Allen, BC, Tirman, P, Clingan, MJ, Manny, J, Del Gaizo, AJ & Leyendecker, JR 2014, 'Characterizing solid renal neoplasms with MRI in adults', Abdominal Imaging, vol. 39, no. 2, pp. 358-387. https://doi.org/10.1007/s00261-014-0074-4
Allen, Brian C. ; Tirman, Philippe ; Clingan, M. Jennings ; Manny, Julia ; Del Gaizo, Andrew J. ; Leyendecker, John R. / Characterizing solid renal neoplasms with MRI in adults. In: Abdominal Imaging. 2014 ; Vol. 39, No. 2. pp. 358-387.
@article{4cb9bd5c478f4623b840af3a1763d3f1,
title = "Characterizing solid renal neoplasms with MRI in adults",
abstract = "Until recently, most solid renal neoplasms without macroscopic fat were presumed to represent renal cell carcinoma and were indiscriminately treated with nephrectomy. Expanding surgical options and ablative technologies, a growing acceptance of renal mass biopsy, the advent of targeted molecular agents, and advances in our understanding of tumor biology have challenged the wisdom of this approach and are ushering in a potential new era in which therapy is linked to histologic subtype and cytogenetics. This approach mandates evolution of our diagnostic algorithm beyond the distinction between solid and cystic and enhancing and nonenhancing. Computed tomography (CT) has traditionally been the imaging technique of choice for evaluating potential solid renal tumors, in large part due to its widespread availability, high spatial resolution, calcium discrimination, and multiphase, enhanced imaging capabilities. For the most part, however, CT is limited to characterization based upon the attenuation and enhancement characteristics of a lesion and necessitates exposure of patients to ionizing radiation. For these latter reasons, multiparametric magnetic resonance imaging (MRI) is being increasingly used to characterize solid renal masses. The purpose of this manuscript is to review our imaging approach to solid renal masses in adults utilizing MRI with an emphasis on a multiparametric approach augmented by clinical data.",
author = "Allen, {Brian C.} and Philippe Tirman and Clingan, {M. Jennings} and Julia Manny and {Del Gaizo}, {Andrew J.} and Leyendecker, {John R.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s00261-014-0074-4",
language = "English (US)",
volume = "39",
pages = "358--387",
journal = "Abdominal Radiology",
issn = "2366-004X",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Characterizing solid renal neoplasms with MRI in adults

AU - Allen, Brian C.

AU - Tirman, Philippe

AU - Clingan, M. Jennings

AU - Manny, Julia

AU - Del Gaizo, Andrew J.

AU - Leyendecker, John R.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Until recently, most solid renal neoplasms without macroscopic fat were presumed to represent renal cell carcinoma and were indiscriminately treated with nephrectomy. Expanding surgical options and ablative technologies, a growing acceptance of renal mass biopsy, the advent of targeted molecular agents, and advances in our understanding of tumor biology have challenged the wisdom of this approach and are ushering in a potential new era in which therapy is linked to histologic subtype and cytogenetics. This approach mandates evolution of our diagnostic algorithm beyond the distinction between solid and cystic and enhancing and nonenhancing. Computed tomography (CT) has traditionally been the imaging technique of choice for evaluating potential solid renal tumors, in large part due to its widespread availability, high spatial resolution, calcium discrimination, and multiphase, enhanced imaging capabilities. For the most part, however, CT is limited to characterization based upon the attenuation and enhancement characteristics of a lesion and necessitates exposure of patients to ionizing radiation. For these latter reasons, multiparametric magnetic resonance imaging (MRI) is being increasingly used to characterize solid renal masses. The purpose of this manuscript is to review our imaging approach to solid renal masses in adults utilizing MRI with an emphasis on a multiparametric approach augmented by clinical data.

AB - Until recently, most solid renal neoplasms without macroscopic fat were presumed to represent renal cell carcinoma and were indiscriminately treated with nephrectomy. Expanding surgical options and ablative technologies, a growing acceptance of renal mass biopsy, the advent of targeted molecular agents, and advances in our understanding of tumor biology have challenged the wisdom of this approach and are ushering in a potential new era in which therapy is linked to histologic subtype and cytogenetics. This approach mandates evolution of our diagnostic algorithm beyond the distinction between solid and cystic and enhancing and nonenhancing. Computed tomography (CT) has traditionally been the imaging technique of choice for evaluating potential solid renal tumors, in large part due to its widespread availability, high spatial resolution, calcium discrimination, and multiphase, enhanced imaging capabilities. For the most part, however, CT is limited to characterization based upon the attenuation and enhancement characteristics of a lesion and necessitates exposure of patients to ionizing radiation. For these latter reasons, multiparametric magnetic resonance imaging (MRI) is being increasingly used to characterize solid renal masses. The purpose of this manuscript is to review our imaging approach to solid renal masses in adults utilizing MRI with an emphasis on a multiparametric approach augmented by clinical data.

UR - http://www.scopus.com/inward/record.url?scp=84897578730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897578730&partnerID=8YFLogxK

U2 - 10.1007/s00261-014-0074-4

DO - 10.1007/s00261-014-0074-4

M3 - Review article

C2 - 24446014

AN - SCOPUS:84897578730

VL - 39

SP - 358

EP - 387

JO - Abdominal Radiology

JF - Abdominal Radiology

SN - 2366-004X

IS - 2

ER -