CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis

Xiaochong Gao, Derek Gordon, Dongping Zhang, Richard Browne, Cynthia Helms, Joseph Gillum, Samuel Weber, Shonn Devroy, Saralove Swaney, Matthew Dobbs, Jose Morcuende, Val Sheffield, Michael Lovett, Anne Bowcock, John Herring, Carol Wise

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103 Citations (Scopus)

Abstract

Idiopathic scoliosis (IS) is the most common spinal deformity in children, and its etiology is unknown. To refine the search for genes underlying IS susceptibility, we ascertained a new cohort of 52 families and conducted a follow-up study of genomewide scans that produced evidence of linkage and association with 8q12 loci (multipoint LOD 2.77; P = .0028). Further fine mapping in the region revealed significant evidence of disease-associated haplotypes (P < 1.0 × 10-4) centering over exons 2-4 of the CHD7 gene associated with the CHARGE (coloboma of the eye, heart defects, atresia of the choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness) syndrome of multiple developmental anomalies. Resequencing CHD7 exons and conserved intronic sequence blocks excluded coding changes but revealed at least one potentially functional polymorphism that is overtransmitted (P = .005) to affected offspring and predicts disruption of a caudal-type (cdx) transcription-factor binding site. Our results identify the first gene associated with IS susceptibility and suggest etiological overlap between the rare, early-onset CHARGE syndrome and common, later-onset IS.

Original languageEnglish (US)
Pages (from-to)957-965
Number of pages9
JournalAmerican Journal of Human Genetics
Volume80
Issue number5
DOIs
StatePublished - May 2007

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Scoliosis
Genes
Exons
CHARGE Syndrome
Coloboma
Nasopharynx
Conserved Sequence
Deafness
Growth and Development
Haplotypes
Ear
Transcription Factors
Binding Sites

ASJC Scopus subject areas

  • Genetics

Cite this

CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis. / Gao, Xiaochong; Gordon, Derek; Zhang, Dongping; Browne, Richard; Helms, Cynthia; Gillum, Joseph; Weber, Samuel; Devroy, Shonn; Swaney, Saralove; Dobbs, Matthew; Morcuende, Jose; Sheffield, Val; Lovett, Michael; Bowcock, Anne; Herring, John; Wise, Carol.

In: American Journal of Human Genetics, Vol. 80, No. 5, 05.2007, p. 957-965.

Research output: Contribution to journalArticle

Gao, X, Gordon, D, Zhang, D, Browne, R, Helms, C, Gillum, J, Weber, S, Devroy, S, Swaney, S, Dobbs, M, Morcuende, J, Sheffield, V, Lovett, M, Bowcock, A, Herring, J & Wise, C 2007, 'CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis', American Journal of Human Genetics, vol. 80, no. 5, pp. 957-965. https://doi.org/10.1086/513571
Gao, Xiaochong ; Gordon, Derek ; Zhang, Dongping ; Browne, Richard ; Helms, Cynthia ; Gillum, Joseph ; Weber, Samuel ; Devroy, Shonn ; Swaney, Saralove ; Dobbs, Matthew ; Morcuende, Jose ; Sheffield, Val ; Lovett, Michael ; Bowcock, Anne ; Herring, John ; Wise, Carol. / CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis. In: American Journal of Human Genetics. 2007 ; Vol. 80, No. 5. pp. 957-965.
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