Stem cells use poised enhancers of developmental regulators to maintain pluripotency and for subsequent activation in differentiating progeny. In this issue of Developmental Cell, Janssens et al. (2017) demonstrate that the erm enhancer is maintained in a poised state in neural stem cells by the histone deacetylase Hdac1/Rpd3.
ASJC Scopus subject areas
- Developmental Biology