Chemical-induced estrogenicity

Stephen H. Safe, Shaheen Khan, Fei Wu, Xiangrong Li

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

17β-estradiol (E2) and the related steroidal hormones play an important role in multiple physiological processes. However, these hormones are risk factors for hormone-dependent diseases including breast and endometrial cancer. Inappropriate exposures (high or low) to estrogens can also lead to adverse health effects. The identification of estrogenic compounds in the environment, coupled with human exposures to these compounds, has generated public, regulatory, and scientific concern regarding their potential hormonal toxicity to humans and wildlife. This chapter focuses on chemical-induced estrogenicity and the potential toxicological impacts of these compounds. It also describes several different structural classes of synthetic estrogenic compounds, phytoestrogens, and estrogens/antiestrogens such as diethylstilbestrol and tamoxifen that are used as pharmaceutical agents. In addition, the mechanism of estrogen action and implications for risk assessment of these compounds are also discussed. These factors highlight the challenges faced by scientists and regulators in addressing the health risks and benefits of estrogenic compounds.

Original languageEnglish (US)
Title of host publicationVeterinary Toxicology
PublisherElsevier Ltd
Pages811-822
Number of pages12
ISBN (Print)9780123704672
DOIs
StatePublished - Dec 1 2007

Fingerprint

estrogens
Estrogens
hormones
diethylstilbestrol
tamoxifen
plant estrogens
Hormones
risk assessment
breasts
estradiol
wildlife
risk factors
adverse effects
Physiological Phenomena
toxicity
Phytoestrogens
drugs
Diethylstilbestrol
neoplasms
Estrogen Receptor Modulators

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Safe, S. H., Khan, S., Wu, F., & Li, X. (2007). Chemical-induced estrogenicity. In Veterinary Toxicology (pp. 811-822). Elsevier Ltd. https://doi.org/10.1016/B978-012370467-2/50162-0

Chemical-induced estrogenicity. / Safe, Stephen H.; Khan, Shaheen; Wu, Fei; Li, Xiangrong.

Veterinary Toxicology. Elsevier Ltd, 2007. p. 811-822.

Research output: Chapter in Book/Report/Conference proceedingChapter

Safe, SH, Khan, S, Wu, F & Li, X 2007, Chemical-induced estrogenicity. in Veterinary Toxicology. Elsevier Ltd, pp. 811-822. https://doi.org/10.1016/B978-012370467-2/50162-0
Safe SH, Khan S, Wu F, Li X. Chemical-induced estrogenicity. In Veterinary Toxicology. Elsevier Ltd. 2007. p. 811-822 https://doi.org/10.1016/B978-012370467-2/50162-0
Safe, Stephen H. ; Khan, Shaheen ; Wu, Fei ; Li, Xiangrong. / Chemical-induced estrogenicity. Veterinary Toxicology. Elsevier Ltd, 2007. pp. 811-822
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