TY - JOUR
T1 - Chemical modification
T2 - The key to clinical application of RNA interference?
AU - Corey, David R.
PY - 2007/12
Y1 - 2007/12
N2 - RNA interference provides a potent and specific method for controlling gene expression in human cells. To translate this potential into a broad new family of therapeutics, it is necessary to optimize the efficacy of the RNA-based drugs. As discussed in this Review, it might be possible to achieve this optimization using chemical modifications that improve their in vivo stability, cellular delivery, biodistribution, pharmacokinetics, potency, and specificity.
AB - RNA interference provides a potent and specific method for controlling gene expression in human cells. To translate this potential into a broad new family of therapeutics, it is necessary to optimize the efficacy of the RNA-based drugs. As discussed in this Review, it might be possible to achieve this optimization using chemical modifications that improve their in vivo stability, cellular delivery, biodistribution, pharmacokinetics, potency, and specificity.
UR - http://www.scopus.com/inward/record.url?scp=36849094017&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36849094017&partnerID=8YFLogxK
U2 - 10.1172/JCI33483
DO - 10.1172/JCI33483
M3 - Article
C2 - 18060019
AN - SCOPUS:36849094017
VL - 117
SP - 3615
EP - 3622
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 12
ER -