Chemical modification: The key to clinical application of RNA interference?

David R. Corey

doi:10.1172/JCI33483

Chemical modification: The key to clinical application of RNA interference?

David R. Corey

Research output: Contribution to journal › Review article

223 Scopus citations

Abstract

RNA interference provides a potent and specific method for controlling gene expression in human cells. To translate this potential into a broad new family of therapeutics, it is necessary to optimize the efficacy of the RNA-based drugs. As discussed in this Review, it might be possible to achieve this optimization using chemical modifications that improve their in vivo stability, cellular delivery, biodistribution, pharmacokinetics, potency, and specificity.

Original language	English (US)
Pages (from-to)	3615-3622
Number of pages	8
Journal	Journal of Clinical Investigation
Volume	117
Issue number	12
DOIs	https://doi.org/10.1172/JCI33483
State	Published - Dec 2007

ASJC Scopus subject areas

Medicine(all)

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10.1172/JCI33483

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Corey, D. R. (2007). Chemical modification: The key to clinical application of RNA interference? Journal of Clinical Investigation, 117(12), 3615-3622. https://doi.org/10.1172/JCI33483

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