Chemical modulation of glycerolipid signaling and metabolic pathways

Sarah A. Scott, Thomas P. Mathews, Pavlina T. Ivanova, Craig W. Lindsley, H. Alex Brown

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Thirty years ago, glycerolipids captured the attention of biochemical researchers as novel cellular signaling entities. We now recognize that these biomolecules occupy signaling nodes critical to a number of physiological and pathological processes. Thus, glycerolipid-metabolizing enzymes present attractive targets for new therapies. A number of fields - ranging from neuroscience and cancer to diabetes and obesity - have elucidated the signaling properties of glycerolipids. The biochemical literature teems with newly emerging small molecule inhibitors capable of manipulating glycerolipid metabolism and signaling. This ever-expanding pool of chemical modulators appears daunting to those interested in exploiting glycerolipid-signaling pathways in their model system of choice. This review distills the current body of literature surrounding glycerolipid metabolism into a more approachable format, facilitating the application of small molecule inhibitors to novel systems. This article is part of a Special Issue entitled Tools to study lipid functions.

Original languageEnglish (US)
Pages (from-to)1060-1084
Number of pages25
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1841
Issue number8
DOIs
StatePublished - Aug 2014
Externally publishedYes

Keywords

  • Autotaxin
  • Fatty acyltransferase
  • Glycerolipid
  • Inhibitor
  • Lipase
  • Lipid kinase
  • Lipin
  • Metabolism
  • Phospholipase

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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