@inbook{6309f397b4af4b9bb057395a87352a48,
title = "Chemical Modulation of WNT Signaling in Cancer",
abstract = "Genetically based observations stemming from defects in development and in regeneration form the foundation of our understanding regarding how the secreted WNT proteins control coordinated cell fate decision-making in adult tissues. At the same time, our anticipation of potential benefits and unwanted toxicities associated with candidate anticancer agents targeting WNT signal transduction are also reliant upon this blueprint of WNT-associated physiology. Despite the long established role of WNT signaling in cancer, the emergence of WNT signaling as a suppressor of immunological attack in melanoma reveals an unanticipated anticancer potential in targeting WNT signaling. Here we review the literature associated with WNT signaling in cancer and discuss potential challenges that may be associated with the chemical attack of this important cellular process in achieving therapeutic goals. Although a number of small molecules targeting WNT signaling are introduced here, we center our discussion on antagonists of the WNT acyltransferase porcupine (PORCN) given the recent entry of two candidate molecules in clinical testing.",
keywords = "APC, RNF43, TCF7L2, WNT, colorectal cancer, dysgeusia, hepatocellular cancer, immunooncology, pancreatic cancer, porcupine, β-catenin",
author = "Zhang, {Li shu} and Lawrence Lum",
note = "Funding Information: We would like to thank Drs. James Kim and Jesung Moon for their insightful comments. This work was supported in part by the Welch Foundation (I-1665) and CPRIT (RP130212). Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R01CA168761, R01CA196851, and P50-CA70907 (Minna). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = jan,
doi = "10.1016/bs.pmbts.2017.11.008",
language = "English (US)",
series = "Progress in Molecular Biology and Translational Science",
publisher = "Elsevier B.V.",
pages = "245--269",
booktitle = "Progress in Molecular Biology and Translational Science",
}