Chemical synthesis of Ser/Thr AMPylated peptides

Rwaida A. Al-Eryani, Yan Li, Haydn L. Ball

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A method for the solid phase chemical synthesis of AMPylated Ser/Thr containing peptides is described. Peptides were phosphonylated using the H-phosphonate method, then the adenosine moiety was introduced using 2′,3′-isopropylidene adenosine and the condensing reagent PyBOP. Oxidation with iodine yielded the desired AMPylated product in good yield following acidolytic cleavage from the resin support.

Original languageEnglish (US)
Pages (from-to)1730-1731
Number of pages2
JournalTetrahedron Letters
Volume51
Issue number13
DOIs
StatePublished - Mar 31 2010

Keywords

  • 2′,3′-Isopropylidene adenosine
  • AMP
  • AMPylation
  • Benzotriazole-1-yl oxy-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBOP)
  • Bis(diethylamino) chlorophosphine
  • H-Phosphonate
  • SPPS

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Chemical synthesis of Ser/Thr AMPylated peptides'. Together they form a unique fingerprint.

  • Cite this