Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

Carol F. Elias, Clifford B. Saper, Eleftheria Maratos-Flier, Nicholas A. Tritos, Charlotte Lee, Joseph Kelly, Jeffrey B. Tatro, Gloria E. Huffman, Michael M. Ollmann, Gregory S. Barsh, Takeshi Sakurai, Masasiii Yanagisawa, Joel K. Elmquist

Research output: Contribution to journalArticle

717 Citations (Scopus)

Abstract

Recent studies have identified several neuropeptide systems in the hypothalamus that are critical in the regulation of body weight. The lateral hypothalamic area (LHA) has long been considered essential in regulating food intake and body weight. Two neuropeptides, melanin-concentrating hormone (MCH) and the orexins (ORX), are localized in the LHA and provide diffuse innervation of the neuraxis, including monosynaptic projections to the cerebral cortex and autonomic preganglionic neurons. Therefore, MCH and ORX neurons may regulate both cognitive and autonomic aspects of food intake and body weight regulation. The arcuate nucleus also is critical in the regulation of body weight, because it contains neurons that express leptin receptors, neuropeptide Y (NPY), α-melanin-stimulating hormone (α-MSH), and agouti-related peptide (AgRP). In this study, we examined the relationships of these peptidergic systems by using dual-label immunohistochemistry or in situ hybridization in rat, mouse, and human brains. In the normal rat, mouse, and human brain, ORX and MCH neurons make up segregated populations. In addition, we found that AgRP- and NPY-immunoreactive neurons are present in the medial division of the human arcuate nucleus, whereas α-MSH- immunoreactive neurons are found in the lateral arcuate nucleus. In humans, AgRP projections were widespread in the hypothalamus, but they were especially dense in the paraventricular nucleus and the perifornical area. Moreover, in both rat and human, MCH and ORX neurons receive innervation from NPY-, AgRP-, and α-MSH-immunoreactive fibers. Projections from populations of leptin-responsive neurons in the mediobasal hypothalamus to MCH and ORX cells in the LHA may link peripheral metabolic cues with the cortical mantle and may play a critical role in the regulation of feeding behavior and body weight.

Original languageEnglish (US)
Pages (from-to)442-459
Number of pages18
JournalJournal of Comparative Neurology
Volume402
Issue number4
DOIs
StatePublished - Dec 28 1998

Fingerprint

Lateral Hypothalamic Area
Hypothalamus
Neurons
Arcuate Nucleus of Hypothalamus
Body Weight
Neuropeptide Y
Melanocyte-Stimulating Hormones
Peptides
Neuropeptides
Eating
Leptin Receptors
Paraventricular Hypothalamic Nucleus
Melanins
Brain
Feeding Behavior
Leptin
Cerebral Cortex
In Situ Hybridization
Cues
Immunohistochemistry

Keywords

  • Arcuate hypothalamic nucleus
  • Feeding
  • Melanin-concentrating hormone
  • Obesity
  • Orexins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. / Elias, Carol F.; Saper, Clifford B.; Maratos-Flier, Eleftheria; Tritos, Nicholas A.; Lee, Charlotte; Kelly, Joseph; Tatro, Jeffrey B.; Huffman, Gloria E.; Ollmann, Michael M.; Barsh, Gregory S.; Sakurai, Takeshi; Yanagisawa, Masasiii; Elmquist, Joel K.

In: Journal of Comparative Neurology, Vol. 402, No. 4, 28.12.1998, p. 442-459.

Research output: Contribution to journalArticle

Elias, CF, Saper, CB, Maratos-Flier, E, Tritos, NA, Lee, C, Kelly, J, Tatro, JB, Huffman, GE, Ollmann, MM, Barsh, GS, Sakurai, T, Yanagisawa, M & Elmquist, JK 1998, 'Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area', Journal of Comparative Neurology, vol. 402, no. 4, pp. 442-459. https://doi.org/10.1002/(SICI)1096-9861(19981228)402:4<442::AID-CNE2>3.0.CO;2-R
Elias, Carol F. ; Saper, Clifford B. ; Maratos-Flier, Eleftheria ; Tritos, Nicholas A. ; Lee, Charlotte ; Kelly, Joseph ; Tatro, Jeffrey B. ; Huffman, Gloria E. ; Ollmann, Michael M. ; Barsh, Gregory S. ; Sakurai, Takeshi ; Yanagisawa, Masasiii ; Elmquist, Joel K. / Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. In: Journal of Comparative Neurology. 1998 ; Vol. 402, No. 4. pp. 442-459.
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AU - Kelly, Joseph

AU - Tatro, Jeffrey B.

AU - Huffman, Gloria E.

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