Chemically induced pluripotent stem cells (CiPSCs): A transgene-free approach

Shigeo Masuda, Jun Wu, Tomoaki Hishida, Ganesh N. Pandian, Hiroshi Sugiyama, Juan Carlos Izpisua Belmonte

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.

Original languageEnglish (US)
Pages (from-to)354-355
Number of pages2
JournalJournal of molecular cell biology
Volume5
Issue number5
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Masuda, S., Wu, J., Hishida, T., Pandian, G. N., Sugiyama, H., & Izpisua Belmonte, J. C. (2013). Chemically induced pluripotent stem cells (CiPSCs): A transgene-free approach. Journal of molecular cell biology, 5(5), 354-355. https://doi.org/10.1093/jmcb/mjt034