Chemistry for DOTA peptide labeling at phenylalanine residues: On the road to preparing peptide ligand tagged libraries

Luis M. De León-Rodríguez, Zoltan Kovacs, Alan D. Sherry

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Different synthetic strategies to control the position of DOTA in phenylalanine residues within a peptide sequence were studied and compared. The results showed that use of DOTA pre-labeled amino acids stands as the most promising procedure for the synthesis of peptide ligand tagged libraries by solid phase peptide synthesis.

Original languageEnglish (US)
Pages (from-to)160-164
Number of pages5
JournalLetters in Organic Chemistry
Volume2
Issue number2
DOIs
StatePublished - Mar 1 2005

Keywords

  • DOTA
  • MRI
  • Peptide
  • Phenylalanine
  • Tag

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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