Chemotherapy-associated hepatotoxicity and hepatic resection for metastatic colorectal cancer

Sam C. Wang, Michael I. D'Angelica

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Approximately 50 % of patients with colorectal cancer will develop liver metastases. Complete resection is associated with 50 % five-year overall survival and 20 % long-term cure. Use of preoperative chemotherapy for patients with resectable colorectal metastasis to the liver is controversial. Among the arguments against use of preoperative chemotherapy is the resulting hepatotoxicity, which may increase the risk of hepatectomy. In this review, we assess the liver-specific toxicity profiles of the most commonly used chemotherapy agents and how this toxicity affects perioperative outcomes. We also comment on the use of neoadjuvant chemotherapy for patients with resectable colorectal metastasis.

Original languageEnglish (US)
Pages (from-to)195-203
Number of pages9
JournalCurrent Colorectal Cancer Reports
Volume10
Issue number2
DOIs
StatePublished - Jun 2014

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Keywords

  • 5-FU
  • 5-Fluorouracil
  • Bevacizumab
  • Cetuximab
  • Chemotherapy-associated hepatotoxicity
  • Chemotherapy-associated steatohepatitis
  • Colorectal liver metastasis
  • HAIP
  • Hepatic artery infusion pump
  • Irinotecan
  • Neoadjuvant therapy
  • Nodular regenerative hyperplasia
  • Oxaliplatin
  • Sinusoidal obstruction syndrome
  • Steatohepatitis
  • Steatosis

ASJC Scopus subject areas

  • Hepatology
  • Oncology
  • Gastroenterology

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