Chemotherapy for extraocular retinoblastoma

Charles B. Pratt, James Fontanesi, Peter Chenaille, Larry E. Kun, Jesse J. Jenkins, James W. Langston, Kevin G. Mounce, David Meyer

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Because few patients with extraocular retinoblastoma are seen in the United Skates and Europe, it has been difficult to establish the optimal role of chemotherapy in such cases. We examined the efficacy of two chemotherapy combinations (cisplatinletoposide and cyclophospha-mide/doxorubicin) in patients with extraretinal retinoblastoma, administered prior to radiotherapy in four patients with recurrent or advanced prinav disease. Responses were evaluable in three patients, each of whom was treated by both chemotherapy regimeas and radiotherapy. Multimodality therapy promises to be of benefit to patients with extraocular retinoblastoma, and future studies will explore alternative chemotherapy combinations for this purpose.

Original languageEnglish (US)
Pages (from-to)301-309
Number of pages9
JournalPediatric Hematology and Oncology
Volume11
Issue number3
DOIs
StatePublished - 1994

Keywords

  • Chemotherapy
  • Metastases
  • Radiation therapy
  • Retinoblastoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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