Chemotherapy for Generalized Infantile Myofibromatosis with Visceral Involvement

Susan Y. Wu; Timothy L. McCavit; Kevin Cederberg; Rene L. Galindo; Patrick J. Leavey

doi:10.1097/MPH.0000000000000132

Chemotherapy for Generalized Infantile Myofibromatosis with Visceral Involvement

Susan Y. Wu, Timothy L. McCavit, Kevin Cederberg, Rene L. Galindo, Patrick J. Leavey

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Infantile myofibromatosis (IM) is most commonly limited to cutaneous lesions that resolve spontaneously. However, generalized IM with visceral involvement, which has a reported mortality rate as high as 73%, has been successfully treated with a combination of methotrexate and vinblastine. Here we report the further efficacy of low-dose methotrexate and vinblastine in 2 pediatric patients with IM and visceral involvement and review the literature describing chemotherapy for these patients.

Original language	English (US)
Pages (from-to)	402-405
Number of pages	4
Journal	Journal of Pediatric Hematology/Oncology
Volume	37
Issue number	5
DOIs	https://doi.org/10.1097/MPH.0000000000000132
State	Published - Jul 11 2015

Keywords

infantile myofibromatosis
methotrexate
pediatrics
vinblastine

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0000000000000132

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abstract = "Infantile myofibromatosis (IM) is most commonly limited to cutaneous lesions that resolve spontaneously. However, generalized IM with visceral involvement, which has a reported mortality rate as high as 73%, has been successfully treated with a combination of methotrexate and vinblastine. Here we report the further efficacy of low-dose methotrexate and vinblastine in 2 pediatric patients with IM and visceral involvement and review the literature describing chemotherapy for these patients.",

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AU - McCavit, Timothy L.

AU - Cederberg, Kevin

AU - Galindo, Rene L.

AU - Leavey, Patrick J.

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AB - Infantile myofibromatosis (IM) is most commonly limited to cutaneous lesions that resolve spontaneously. However, generalized IM with visceral involvement, which has a reported mortality rate as high as 73%, has been successfully treated with a combination of methotrexate and vinblastine. Here we report the further efficacy of low-dose methotrexate and vinblastine in 2 pediatric patients with IM and visceral involvement and review the literature describing chemotherapy for these patients.

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KW - vinblastine

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Chemotherapy for Generalized Infantile Myofibromatosis with Visceral Involvement

Abstract

Keywords

ASJC Scopus subject areas

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