Abstract
Children with acute lymphocytic leukemia who fail to enter remission have a poor prognosis. In a previous study, 9 of 14 children with induction failure entered remission after teniposide (VM26) plus cytosine arabinoside (Ara-C). We attempted to confirm these results. Twenty children received teniposide (200 mg/m/day IV) for 3 days and cytosine arabinoside (100 mg/m/day continuous IV infusion) for 7 days. There were 3 complete and 3 partial responses. Two additional patients achieved a complete response after a second, shorter course of the same agents. Although VM26 plus Ara-C is an active combination for treatment of acute lymphocytic leukemia induction failure, it does not appear as effective as in the initial report. Better treatments for this problem are needed.
Original language | English (US) |
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Pages (from-to) | 32-35 |
Number of pages | 4 |
Journal | Journal of Pediatric Hematology/Oncology |
Volume | 35 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2013 |
Keywords
- acute lymphoblastic leukemia
- chemotherapy
- induction failure
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology