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- Pediatrics, Perinatology, and Child Health
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Childhood chronic lymphocytic leukemia with t(2; 14) translocation. / Yoffe, Galina; Howard-Peebles, Patricia N.; Smith, R. Graham; Tucker, Philip W.; Buchanan, George R.In: The Journal of pediatrics, Vol. 116, No. 1, 01.1990, p. 114-117.
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TY - JOUR
T1 - Childhood chronic lymphocytic leukemia with t(2; 14) translocation
AU - Yoffe, Galina
AU - Howard-Peebles, Patricia N.
AU - Smith, R. Graham
AU - Tucker, Philip W.
AU - Buchanan, George R.
N1 - Funding Information: CASE REPORTS Patient 1. A 10-year-old white girl came in March 1982 to the Children's Medical Center of Dallas with generalized lymphadenopathy, mild hepatosplenomegaly, hypogammaglobulinemia, and leukocytosis (leukocyte count 35,900/mm 3 with 88% small mature Supported in part by an American Cancer Society Clinical Fellowship granted to Dr. Yoffe and by the Children's Cancer Fund of Dallas. Submitted for publication June 2, 1989; accepted July 13, 1989. Reprint requests: George R. Buchanan, MD, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235-9063. 9/22/15256 lymphocytes on the peripheral blood smear.) Chromosomal analysis revealed transloeation t(2;14) with breakpoints at or near the kappa light-chain and heavy-chain gene loci. Subsequent molecular analysis revealed the breakpoints within a DNA sequence telomere to the immunoglobulin kappa llght-chain locus on chromosome 2.12 The detailed morphologic description and immunologic studies that established the diagnosis of CLL and an account of the initial management of this patient were published previously. 8 During the first year after diagnosis, the disease was indolent and required no therapy. However, in the second and third year, disease progression was noted. Oral chemotherapy with prednisone and chlorambucil was instituted, and the patient achieved a rapid response, remaining well (but requiring continued chlorambucil) for almost 4 years. Subsequently, the disease progressed and became Copyright: Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1990/1
Y1 - 1990/1
UR - http://www.scopus.com/inward/record.url?scp=0025117712&partnerID=8YFLogxK
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U2 - 10.1016/S0022-3476(05)81658-0
DO - 10.1016/S0022-3476(05)81658-0
M3 - Article
C2 - 2295951
AN - SCOPUS:0025117712
VL - 116
SP - 114
EP - 117
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 1