TY - JOUR
T1 - Children With Down Syndrome and Obstructive Sleep Apnea
T2 - Outcomes After Tonsillectomy
AU - Abijay, Claire A.
AU - Tomkies, Anna
AU - Rayasam, Swathi
AU - Johnson, Romaine F.
AU - Mitchell, Ron B.
N1 - Publisher Copyright:
© American Academy of Otolaryngology–Head and Neck Surgery Foundation 2021.
PY - 2022/3
Y1 - 2022/3
N2 - Objective: To evaluate outcomes of tonsillectomy and predictors for persistent obstructive sleep apnea (OSA) in children with Down syndrome in an ethnically diverse population. Study Design: Case series with chart review. Setting: UT Southwestern/Children’s Medical Center Dallas. Methods: Polysomnographic, clinical, and demographic characteristics of children with Down syndrome ages 1 to 18 years were collected, including pre- and postoperative polysomnography. Simple and multivariable regression models were used for predictors for persistent OSA. P≤.05 was considered significant. Results: Eighty-one children were included with a mean age of 6.6 years, 44 of 81 (54%) males, and 53 of 81 (65%) Hispanic. Preoperatively, 60 of 81 (74%) patients had severe OSA. Posttonsillectomy improvements occurred for apnea-hypopnea index (27.9 to 14.0, P <.001), arousal index (25.2 to 18.8, P =.004), percent time with oxygen saturations <90% (8.8% to 3.4%, P =.003), and oxygen nadir (81.4% to 85%, P <.001). Forty-seven children (58%) had persistent OSA. Fifteen children (18.5%) had increased apnea-hypopnea index postoperatively: 2 from mild to moderate, 2 from mild to severe, and 2 from moderate to severe obstructive sleep apnea. Persistent OSA predictors were asthma (odds ratio, 4.77; 95% CI, 1.61-14.09; P =.005) and increasing age (odds ratio, 1.25; 95% CI, 1.09-1.43; P =.001). Conclusion: Children with Down syndrome are at high risk for persistent OSA after tonsillectomy with about 20% worsening after tonsillectomy. Asthma and increasing age are predictors for persistent OSA in children with Down syndrome.
AB - Objective: To evaluate outcomes of tonsillectomy and predictors for persistent obstructive sleep apnea (OSA) in children with Down syndrome in an ethnically diverse population. Study Design: Case series with chart review. Setting: UT Southwestern/Children’s Medical Center Dallas. Methods: Polysomnographic, clinical, and demographic characteristics of children with Down syndrome ages 1 to 18 years were collected, including pre- and postoperative polysomnography. Simple and multivariable regression models were used for predictors for persistent OSA. P≤.05 was considered significant. Results: Eighty-one children were included with a mean age of 6.6 years, 44 of 81 (54%) males, and 53 of 81 (65%) Hispanic. Preoperatively, 60 of 81 (74%) patients had severe OSA. Posttonsillectomy improvements occurred for apnea-hypopnea index (27.9 to 14.0, P <.001), arousal index (25.2 to 18.8, P =.004), percent time with oxygen saturations <90% (8.8% to 3.4%, P =.003), and oxygen nadir (81.4% to 85%, P <.001). Forty-seven children (58%) had persistent OSA. Fifteen children (18.5%) had increased apnea-hypopnea index postoperatively: 2 from mild to moderate, 2 from mild to severe, and 2 from moderate to severe obstructive sleep apnea. Persistent OSA predictors were asthma (odds ratio, 4.77; 95% CI, 1.61-14.09; P =.005) and increasing age (odds ratio, 1.25; 95% CI, 1.09-1.43; P =.001). Conclusion: Children with Down syndrome are at high risk for persistent OSA after tonsillectomy with about 20% worsening after tonsillectomy. Asthma and increasing age are predictors for persistent OSA in children with Down syndrome.
KW - Down syndrome
KW - asthma
KW - obstructive sleep apnea
KW - pediatrics
KW - tonsillectomy and adenoidectomy
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U2 - 10.1177/01945998211023102
DO - 10.1177/01945998211023102
M3 - Article
C2 - 34253070
AN - SCOPUS:85109806782
SN - 0194-5998
VL - 166
SP - 557
EP - 564
JO - Otolaryngology - Head and Neck Surgery (United States)
JF - Otolaryngology - Head and Neck Surgery (United States)
IS - 3
ER -