Children with partial IgA deficiency: Clinical characteristics observed in the pediatric rheumatology clinic

Aarti Shakkottai, Krishnaveni Bupathi, Ankit P. Patel, Elizabeth Chalom, Suneetha Chamarthi, Thomas J.A. Lehman, Margaret G.E. Peterson, Sunanda Gaur, Lakshmi N. Moorthy

Research output: Contribution to journalReview articlepeer-review

Abstract

Literature is lacking on partial IgA deficiency. In this study, the authors propose to describe the clinical manifestations of patients with partial IgA deficiency. Methods. The authors conducted a retrospective chart review of 13 patients with partial IgA deficiency followed at the pediatric rheumatology clinic at Robert Wood Johnson Medical School. They looked for the presence of rashes, joint pain, joint swelling, and morning stiffness. The authors also examined charts for a history of frequent infections, allergies, and the presence of elevated antinuclear antibody. Results. Eleven out of the 13 patients complained of joint pain, joint swelling, or morning stiffness. Six patients carried a diagnosis of a definitive rheumatic disease. Four patients suffered from frequent infections and 2 patients reported allergies. Conclusion. Partial IgA deficiency appears to be associated with rheumatic diseases and complaints of joint pain, joint swelling, and morning stiffness. A larger study is needed to confirm these results.

Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalClinical Pediatrics
Volume51
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • partial IgA deficiency
  • rheumatic disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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