Chiral acetals: Stereocontrolled syntheses of 16-, 17-, and 18-hydroxyeicosatetraenoic acids, cytochrome P-450 arachidonate metabolites

Bertrand Heckmann, Charles Mioskowski, Sun Lumin, J R Falck, Shouzou Wei, Jorge H. Capdevila

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Chiral adducts from Grignard or allylsilane additions to 1,3-dioxan/1,3-dioxolan-4-ones were exploited for the total synthesis of the R- and S-isomers of the title eicosanoids.

Original languageEnglish (US)
Pages (from-to)1425-1428
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number9
DOIs
StatePublished - Feb 26 1996

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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