Chiral acetals: Stereocontrolled syntheses of 16-, 17-, and 18-hydroxyeicosatetraenoic acids, cytochrome P-450 arachidonate metabolites

Bertrand Heckmann, Charles Mioskowski, Sun Lumin, J R Falck, Shouzou Wei, Jorge H. Capdevila

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Chiral adducts from Grignard or allylsilane additions to 1,3-dioxan/1,3-dioxolan-4-ones were exploited for the total synthesis of the R- and S-isomers of the title eicosanoids.

Original languageEnglish (US)
Pages (from-to)1425-1428
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number9
DOIs
StatePublished - Feb 26 1996

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Acetals
Eicosanoids
Metabolites
Isomers
Cytochrome P-450 Enzyme System
allylsilane
18-hydroxy-5,8,11,14-eicosatetraenoic acid
1,4-dioxane

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Chiral acetals : Stereocontrolled syntheses of 16-, 17-, and 18-hydroxyeicosatetraenoic acids, cytochrome P-450 arachidonate metabolites. / Heckmann, Bertrand; Mioskowski, Charles; Lumin, Sun; Falck, J R; Wei, Shouzou; Capdevila, Jorge H.

In: Tetrahedron Letters, Vol. 37, No. 9, 26.02.1996, p. 1425-1428.

Research output: Contribution to journalArticle

Heckmann, Bertrand ; Mioskowski, Charles ; Lumin, Sun ; Falck, J R ; Wei, Shouzou ; Capdevila, Jorge H. / Chiral acetals : Stereocontrolled syntheses of 16-, 17-, and 18-hydroxyeicosatetraenoic acids, cytochrome P-450 arachidonate metabolites. In: Tetrahedron Letters. 1996 ; Vol. 37, No. 9. pp. 1425-1428.
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