Chk1: A Double Agent in Cell Cycle Checkpoints

Hongtao Yu

doi:10.1016/j.devcel.2007.01.005

Chk1: A Double Agent in Cell Cycle Checkpoints

Hongtao Yu

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al. (2007) present evidence to indicate that Chk1 also plays a critical role in the spindle checkpoint, suggesting an interplay between the DNA damage and spindle checkpoints.

Original language	English (US)
Pages (from-to)	167-168
Number of pages	2
Journal	Developmental cell
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2007.01.005
State	Published - Feb 2007

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2007.01.005

Cite this

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title = "Chk1: A Double Agent in Cell Cycle Checkpoints",

abstract = "Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al. (2007) present evidence to indicate that Chk1 also plays a critical role in the spindle checkpoint, suggesting an interplay between the DNA damage and spindle checkpoints.",

author = "Hongtao Yu",

year = "2007",

month = feb,

doi = "10.1016/j.devcel.2007.01.005",

language = "English (US)",

volume = "12",

pages = "167--168",

journal = "Developmental cell",

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publisher = "Cell Press",

number = "2",

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T2 - A Double Agent in Cell Cycle Checkpoints

AU - Yu, Hongtao

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AB - Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al. (2007) present evidence to indicate that Chk1 also plays a critical role in the spindle checkpoint, suggesting an interplay between the DNA damage and spindle checkpoints.

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DO - 10.1016/j.devcel.2007.01.005

M3 - Short survey

C2 - 17276330

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SN - 1534-5807

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SP - 167

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JO - Developmental cell

JF - Developmental cell

IS - 2

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Chk1: A Double Agent in Cell Cycle Checkpoints

Abstract

ASJC Scopus subject areas

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