Cholesterogenesis: Derepression in extrahepatic tissues with 4-aminopyrazolo[3,4-d]pyrimidine

John M. Andersen, John M. Dietschy

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Abstract

Administration of 4-aminopyrazolo[3,4-d]pyrimidine decreased serum cholesterol levels in the rat to less than 5 milligrams per deciliter. Coincident with this change, there was a 2.1- to 16.0-fold increase in the rate of sterol synthesis in seven extrahepatic tissues. This suggests that cholesterol carried in serum lipoproteins plays a major role in regulating sterol synthesis in many extrahepatic tissues.

Original languageEnglish (US)
Pages (from-to)903-905
Number of pages3
JournalScience
Volume193
Issue number4256
Publication statusPublished - 1976

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