A technique for direct sampling of gallbladder and hepatic bile in humans provides strong support for the view that gallstones develop when bile becomes lithogenic, i.e., when the bile acid phospholipid to cholesterol ratio exceeds 10:1. Lithogenic bile may develop in normal persons through diurnal variation in bile lipid composition or result from excess secretion of biliary cholesterol and/or bile acid deficiency.
|Original language||English (US)|
|Number of pages||9|
|State||Published - Jan 1 1973|
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