Cholesterol metabolism and embryogenesis

Robert V. Farese, Joachim Herz

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

Although cholesterol has long been known to be an essential component of cell membranes in vertebrate organisms, recent studies have suggested that cholesterol plays a crucial role in specific processes during embryonic development, including the covalent modification of Hedgebog proteins. Here we review the overlapping developmental phenotypes associated with pharmacologically or genetically induced defects in cholesterol biosynthesis, embryonic cholesterol transport and Hedgebog proteins. Shared aspects of these phenotypes suggest that common mechanisms underlie impaired central nervous system development associated with cholesterol deficiency.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalTrends in Genetics
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 1 1998

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ASJC Scopus subject areas

  • Genetics

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