Choline molecular imaging with small-animal PET for monitoring tumor cellular response to photodynamic therapy of cancer

Baowei Fei, Hesheng Wang, Chunying Wu, Joseph Meyers, Liang Yan Xue, Gregory MacLennan, Mark Schluchter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

We are developing and evaluating choline molecular imaging with positron emission tomography (PET) for monitoring tumor response to photodynamic therapy (PDT) in animal models. Human prostate cancer (PC-3) was studied in athymic nude mice. A second-generation photosensitizer Pc 4 was used for PDT in tumor-bearing mice. MicroPET images with 11C-choline were acquired before PDT and 48 h after PDT. Time-activity curves of 11C-choline uptake were analyzed before and after PDT. For treated tumors, normalized choline uptake decreased significantly 48 h after PDT, compared to the same tumors pre-PDT (p < 0.001). However, for the control tumors, normalized choline uptake increased significantly (p < 0.001). PET imaging with 11C-choline is sensitive to detect early tumor response to PDT in the animal model of human prostate cancer.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
DOIs
StatePublished - Jun 22 2009
Externally publishedYes
EventMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
Duration: Feb 8 2009Feb 10 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7262
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/8/092/10/09

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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