@inproceedings{c96a0de5799945039dc86254be2cf59e,
title = "Choline molecular imaging with small-animal PET for monitoring tumor cellular response to photodynamic therapy of cancer",
abstract = "We are developing and evaluating choline molecular imaging with positron emission tomography (PET) for monitoring tumor response to photodynamic therapy (PDT) in animal models. Human prostate cancer (PC-3) was studied in athymic nude mice. A second-generation photosensitizer Pc 4 was used for PDT in tumor-bearing mice. MicroPET images with 11C-choline were acquired before PDT and 48 h after PDT. Time-activity curves of 11C-choline uptake were analyzed before and after PDT. For treated tumors, normalized choline uptake decreased significantly 48 h after PDT, compared to the same tumors pre-PDT (p < 0.001). However, for the control tumors, normalized choline uptake increased significantly (p < 0.001). PET imaging with 11C-choline is sensitive to detect early tumor response to PDT in the animal model of human prostate cancer.",
author = "Baowei Fei and Hesheng Wang and Chunying Wu and Joseph Meyers and Xue, {Liang Yan} and Gregory MacLennan and Mark Schluchter",
year = "2009",
doi = "10.1117/12.812129",
language = "English (US)",
isbn = "9780819475138",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Medical Imaging 2009",
note = "Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging ; Conference date: 08-02-2009 Through 10-02-2009",
}