Cholinergic influences in tardive dyskinesia

C. A. Tamminga, R. C. Smith, S. E. Ericksen, S. Chang, J. M. Davis

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The authors conducted placebo-controlled double-blind studies of physostigmine, choline, and deanol in 12 patients with tardive dyskinesia. Physostigmine and choline both had a positive therapeutic effect on tardive dyskinesia, but the authors note that interpretation of these results is not entirely clear because they found that the sedation effect of physostigmine may nonspecifically reduce the intensity of tardive dyskinesia symptoms. Deanol was not found to be effective in this group of patients; the authors suggest that this drug should not be assumed to be generally effective unless effectiveness is verified by a large placebo-controlled double-blind study.

Original languageEnglish (US)
Pages (from-to)769-774
Number of pages6
JournalAmerican Journal of Psychiatry
Volume134
Issue number7
StatePublished - 1977

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Physostigmine
Deanol
Cholinergic Agents
Choline
Double-Blind Method
Placebos
Therapeutic Uses
Pharmaceutical Preparations
Tardive Dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Tamminga, C. A., Smith, R. C., Ericksen, S. E., Chang, S., & Davis, J. M. (1977). Cholinergic influences in tardive dyskinesia. American Journal of Psychiatry, 134(7), 769-774.

Cholinergic influences in tardive dyskinesia. / Tamminga, C. A.; Smith, R. C.; Ericksen, S. E.; Chang, S.; Davis, J. M.

In: American Journal of Psychiatry, Vol. 134, No. 7, 1977, p. 769-774.

Research output: Contribution to journalArticle

Tamminga, CA, Smith, RC, Ericksen, SE, Chang, S & Davis, JM 1977, 'Cholinergic influences in tardive dyskinesia', American Journal of Psychiatry, vol. 134, no. 7, pp. 769-774.
Tamminga CA, Smith RC, Ericksen SE, Chang S, Davis JM. Cholinergic influences in tardive dyskinesia. American Journal of Psychiatry. 1977;134(7):769-774.
Tamminga, C. A. ; Smith, R. C. ; Ericksen, S. E. ; Chang, S. ; Davis, J. M. / Cholinergic influences in tardive dyskinesia. In: American Journal of Psychiatry. 1977 ; Vol. 134, No. 7. pp. 769-774.
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