Cholinergic innervation displays strikingly different laminar preferences in several cortical areas

A. Lysakowski, B. H. Wainer, D. B. Rye, G. Bruce, L. B. Hersh

Research output: Contribution to journalArticle

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A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.

Original languageEnglish (US)
Pages (from-to)102-108
Number of pages7
JournalNeuroscience Letters
Issue number1
StatePublished - Feb 14 1986



  • acetylcholine
  • acetylcholinesterase
  • choline acetyltransferase
  • cholinergic system
  • cortical organization
  • rat

ASJC Scopus subject areas

  • Neuroscience(all)

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