Cholinergic innervation displays strikingly different laminar preferences in several cortical areas

A. Lysakowski, B. H. Wainer, D. B. Rye, G. Bruce, L. B. Hersh

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.

Original languageEnglish (US)
Pages (from-to)102-108
Number of pages7
JournalNeuroscience Letters
Volume64
Issue number1
DOIs
StatePublished - Feb 14 1986

Fingerprint

Cholinergic Agents
Choline O-Acetyltransferase
Cholinergic Fibers
Staining and Labeling
Neocortex
Acetylcholinesterase
Cerebral Cortex
Immune Sera
Rabbits

Keywords

  • acetylcholine
  • acetylcholinesterase
  • choline acetyltransferase
  • cholinergic system
  • cortical organization
  • rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cholinergic innervation displays strikingly different laminar preferences in several cortical areas. / Lysakowski, A.; Wainer, B. H.; Rye, D. B.; Bruce, G.; Hersh, L. B.

In: Neuroscience Letters, Vol. 64, No. 1, 14.02.1986, p. 102-108.

Research output: Contribution to journalArticle

Lysakowski, A. ; Wainer, B. H. ; Rye, D. B. ; Bruce, G. ; Hersh, L. B. / Cholinergic innervation displays strikingly different laminar preferences in several cortical areas. In: Neuroscience Letters. 1986 ; Vol. 64, No. 1. pp. 102-108.
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