Choreoathetosis as a side effect of gabapentin therapy in severely neurologically impaired patients

Robert S. Chudnow, Richard B. Dewey, Craig R. Lawson

Research output: Contribution to journalArticle

42 Scopus citations


Objective: To evaluate the relationship of gabapentin therapy with choreoathetotic movements in mentally retarded patients treated for intractable epilepsy. Design: Case reports of 2 institutionalized patients who developed choreoathetosis temporally related in adjunctive therapy with gabapentin at dosages of 1200 to 1800 mg/d. Results: Both patients experienced resolution of abnormal movements on discontinuation of the therapy. One patient developed recurrent choreiform movements after drug rechallenge. Conclusion: We suggest that, in patients with mental retardation and epilepsy, involuntary movements may either occur as reversible side effects of gabapentin therapy or result from a previously undescribed adverse drug interaction with other antiepileptic agents.

Original languageEnglish (US)
Pages (from-to)910-912
Number of pages3
JournalArchives of neurology
Issue number7
StatePublished - Aug 2 1997


ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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