Objective: To evaluate the relationship of gabapentin therapy with choreoathetotic movements in mentally retarded patients treated for intractable epilepsy. Design: Case reports of 2 institutionalized patients who developed choreoathetosis temporally related in adjunctive therapy with gabapentin at dosages of 1200 to 1800 mg/d. Results: Both patients experienced resolution of abnormal movements on discontinuation of the therapy. One patient developed recurrent choreiform movements after drug rechallenge. Conclusion: We suggest that, in patients with mental retardation and epilepsy, involuntary movements may either occur as reversible side effects of gabapentin therapy or result from a previously undescribed adverse drug interaction with other antiepileptic agents.
|Original language||English (US)|
|Number of pages||3|
|Journal||Archives of neurology|
|State||Published - Aug 2 1997|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology