TY - JOUR
T1 - Chorioamnionitis and neonatal encephalopathy in term infants with fetal acidemia
T2 - Histopathologic correlations
AU - Shalak, Lina
AU - Johnson-Welch, Sarah
AU - Perlman, Jeffrey M.
PY - 2005/9
Y1 - 2005/9
N2 - The aim of this study was to determine whether the presence or severity of histologic abnormalities of infection/inflammation such as chorioamnionitis, vasculitis, or funisitis confers an additional risk for neonatal encephalopathy in term infants delivered in the presence of severe fetal acidosis. The medical records as well as placental pathology of term infants (n = 51) born with a cord umbilical arterial pH <7.00 were reviewed. Abnormal outcome was predefined as Sarnat stage 2 or 3 neonatal encephalopathy in the first week of life or neonatal death as a consequence of severe brain injury. Consistent with prior data, the presence of severe fetal acidemia, a low 5-minute Apgar score, and need for cardiopulmonary resuscitation were significantly associated with neonatal encephalopathy. However, the presence of histologic chorioamnionitis had a poor predictive value and did not confer additional risk for the subsequent development of neonatal encephalopathy.
AB - The aim of this study was to determine whether the presence or severity of histologic abnormalities of infection/inflammation such as chorioamnionitis, vasculitis, or funisitis confers an additional risk for neonatal encephalopathy in term infants delivered in the presence of severe fetal acidosis. The medical records as well as placental pathology of term infants (n = 51) born with a cord umbilical arterial pH <7.00 were reviewed. Abnormal outcome was predefined as Sarnat stage 2 or 3 neonatal encephalopathy in the first week of life or neonatal death as a consequence of severe brain injury. Consistent with prior data, the presence of severe fetal acidemia, a low 5-minute Apgar score, and need for cardiopulmonary resuscitation were significantly associated with neonatal encephalopathy. However, the presence of histologic chorioamnionitis had a poor predictive value and did not confer additional risk for the subsequent development of neonatal encephalopathy.
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U2 - 10.1016/j.pediatrneurol.2005.04.005
DO - 10.1016/j.pediatrneurol.2005.04.005
M3 - Article
C2 - 16139729
AN - SCOPUS:27644453450
SN - 0887-8994
VL - 33
SP - 162
EP - 165
JO - Pediatric Neurology
JF - Pediatric Neurology
IS - 3
ER -