Choroid plexus carcinoma

Purva Gopal, John R. Parker, Robert Debski, Joseph C. Parker

Research output: Contribution to journalShort survey

41 Scopus citations

Abstract

Choroid plexus carcinoma is an uncommon neoplasm of the central nervous system most commonly found in the pediatric population. It is associated with a dismal prognosis, especially if incompletely resected. Accurate histopathologic diagnosis is imperative, and this neoplasm should always be included in the differential diagnosis of a papillary intraventricular tumor. Histopathologic features include blurring of papillary architecture, layers of neoplastic choroid plexus epithelial cells with pleomorphic nuclei, increased nuclear-to-cytoplasmic ratio, increased mitotic activity, areas of necrosis, and brain invasion. Current accepted treatment is gross total surgical resection of the tumor as the goal. Use of adjuvant chemotherapy is controversial at this time; however, it is considered in some cases.

Original languageEnglish (US)
Pages (from-to)1350-1354
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume132
Issue number8
StatePublished - Aug 1 2008

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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    Gopal, P., Parker, J. R., Debski, R., & Parker, J. C. (2008). Choroid plexus carcinoma. Archives of Pathology and Laboratory Medicine, 132(8), 1350-1354.