Chromatin remodeling in neural development and plasticity

Jenny Hsieh, Fred H. Gage

Research output: Contribution to journalReview article

170 Scopus citations

Abstract

Neural stem cells generate distinct cell types for tissue formation and cell replacement during development and throughout adulthood. Neural development and plasticity are determined by both extrinsic and intrinsic factors that interface to regulate gene programs for controlling neuronal cell fate and function. Recent reports have shown that chromatin remodeling and epigenetic gene regulation play an important role in such diverse areas as neural cell fate specification and synaptic development and function. These epigenetic mechanisms include cell-type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and the activity of retrotransposons.

Original languageEnglish (US)
Pages (from-to)664-671
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume17
Issue number6
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Cell Biology

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