Gruber et al. identify EGF-independent proliferation in mammary cells following transient BRCA2 depletion (“BRCA2-crisis”). In the absence of recurrent genomic mutations, chromatin remodeling mediated by NF-κB signaling drives gene expression changes. This in vitro model shares molecular commonalities observed in BRCA2+/− carriers.
- breast cancer
- histone acetylation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)