Chromatin Remodeling in Response to BRCA2-Crisis

Joshua J. Gruber, Justin Chen, Benjamin Geller, Natalie Jäger, Andrew M. Lipchik, Guangwen Wang, Allison W. Kurian, James M. Ford, Michael P. Snyder

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Gruber et al. identify EGF-independent proliferation in mammary cells following transient BRCA2 depletion (“BRCA2-crisis”). In the absence of recurrent genomic mutations, chromatin remodeling mediated by NF-κB signaling drives gene expression changes. This in vitro model shares molecular commonalities observed in BRCA2+/− carriers.

Original languageEnglish (US)
Pages (from-to)2182-2193.e6
JournalCell Reports
Issue number8
StatePublished - Aug 20 2019
Externally publishedYes


  • BRCA2
  • breast cancer
  • carcinogenesis
  • epigenetics
  • H4K12Ac
  • haploinsufficiency
  • histone acetylation
  • NF-κB

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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