@article{1aff79c6081647748f1440271c4dc8ce,
title = "Chromatin Remodeling in Response to BRCA2-Crisis",
abstract = "Gruber et al. identify EGF-independent proliferation in mammary cells following transient BRCA2 depletion (“BRCA2-crisis”). In the absence of recurrent genomic mutations, chromatin remodeling mediated by NF-κB signaling drives gene expression changes. This in vitro model shares molecular commonalities observed in BRCA2+/− carriers.",
keywords = "BRCA2, breast cancer, carcinogenesis, epigenetics, H4K12Ac, haploinsufficiency, histone acetylation, NF-κB",
author = "Gruber, {Joshua J.} and Justin Chen and Benjamin Geller and Natalie J{\"a}ger and Lipchik, {Andrew M.} and Guangwen Wang and Kurian, {Allison W.} and Ford, {James M.} and Snyder, {Michael P.}",
note = "Funding Information: M.P.S. is a co-founder and scientific advisory board member of Personalis, SensOmics, Qbio, January, Akna, Filtricine, and Tailai. M.P.S. is on the scientific advisory board of Genapsys and Jupiter. M.P.S. owns stock in Abcam and Epinomics. J.J.G. and M.P.S. are supported by a grant from Curis, Inc. All other authors declare no competing interests. Funding Information: This work used the Genome Sequencing Service Center by the Stanford Center for Genomics and Personalized Medicine Sequencing Center, supported by the NIH grant award S10OD020141 . ATR inhibitors were a gift from Karlene Cimprich. J.J.G. was supported by fellowships from the Jane Coffin Childs Memorial Fund for Medical Research , the Stanford Cancer Institute , and the Susan G. Komen Foundation , as well as funding from ASCO , the Conquer Cancer Foundation , and the Breast Cancer Research Foundation . J.M.F. is supported by the Breast Cancer Research Foundation and the BRCA Foundation . M.P.S. is supported by grants from the NIH , including a Centers of Excellence in Genomic Science award ( 5P50HG00773502 ). Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = aug,
day = "20",
doi = "10.1016/j.celrep.2019.07.057",
language = "English (US)",
volume = "28",
pages = "2182--2193.e6",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "8",
}