Chromatin-tethered MAPKs

Aileen M. Klein, Elma Zaganjor, Melanie H. Cobb

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that are essential nodes in many cellular regulatory circuits including those that take place on DNA. Most members of the four MAPK subgroups that exist in canonical three kinase cascades - extracellular signalregulated kinases 1 and 2 (ERK1/2), ERK5, c-Jun N-terminal kinases (JNK1-3), and p38 (α, β, γ, and δ) families - have been shown to perform regulatory functions on chromatin. This review offers a brief update on the variety of processes that involve MAPKs and available mechanisms garnered in the last two years.

Original languageEnglish (US)
Pages (from-to)272-277
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume25
Issue number2
DOIs
Publication statusPublished - 2013

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ASJC Scopus subject areas

  • Cell Biology

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