Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

N. K. Honey, A. Y. Sakaguchi, P. A. Lalley, C. Quinto, R. J. MacDonald, C. Craik, G. I. Bell, W. J. Rutter, S. L. Naylor

Research output: Contribution to journalArticle

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Abstract

The mouse genes for the serine proteases trypsin (Try-1, chymotrypsin B (Ctrb), and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.

Original languageEnglish (US)
Pages (from-to)377-383
Number of pages7
JournalSomatic Cell and Molecular Genetics
Volume10
Issue number4
DOIs
StatePublished - Jul 1984

Fingerprint

Pancreatic Elastase
Trypsin
Hybrid Cells
Genes
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 8
Chromosome Segregation
Chromosomes, Human, Pair 6
DNA
Serine Proteases
Human Genome
Southern Blotting
Cricetulus
Complementary DNA
chymotrypsin B

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Honey, N. K., Sakaguchi, A. Y., Lalley, P. A., Quinto, C., MacDonald, R. J., Craik, C., ... Naylor, S. L. (1984). Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. Somatic Cell and Molecular Genetics, 10(4), 377-383. https://doi.org/10.1007/BF01535633

Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. / Honey, N. K.; Sakaguchi, A. Y.; Lalley, P. A.; Quinto, C.; MacDonald, R. J.; Craik, C.; Bell, G. I.; Rutter, W. J.; Naylor, S. L.

In: Somatic Cell and Molecular Genetics, Vol. 10, No. 4, 07.1984, p. 377-383.

Research output: Contribution to journalArticle

Honey, NK, Sakaguchi, AY, Lalley, PA, Quinto, C, MacDonald, RJ, Craik, C, Bell, GI, Rutter, WJ & Naylor, SL 1984, 'Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse', Somatic Cell and Molecular Genetics, vol. 10, no. 4, pp. 377-383. https://doi.org/10.1007/BF01535633
Honey, N. K. ; Sakaguchi, A. Y. ; Lalley, P. A. ; Quinto, C. ; MacDonald, R. J. ; Craik, C. ; Bell, G. I. ; Rutter, W. J. ; Naylor, S. L. / Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. In: Somatic Cell and Molecular Genetics. 1984 ; Vol. 10, No. 4. pp. 377-383.
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