Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase

N. K. Honey, A. Y. Sakaguchi, C. Quinto, R. J. MacDonald, G. I. Bell, C. Craik, W. J. Rutter, S. L. Naylor

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Abstract

The genes for the serine proteases trypsin, chymotrypsin B, and elastase were chromosomally assigned in man using cDNA probes that have been isolated from a rat pancreatic cDNA library. DNA from human × rodent somatic cell hybrids was cleaved with BamHI or EcoRI and analyzed by Southern filter hybridization methods for the segregation of the genes for trypsin-1 (TRY1), chymotrypsin B (CTRB), and elastase-1 (ELA1). TRY1 was assigned to human chromosome 7q22→qter, CTRB to chromosome 16, and ELA1 to chromosome 12. Although the three genes are members of the same gene family, they are dispersed over different chromosomes.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalSomatic Cell and Molecular Genetics
Volume10
Issue number4
DOIs
Publication statusPublished - Jul 1984

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ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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