Abstract
The genes for the serine proteases trypsin, chymotrypsin B, and elastase were chromosomally assigned in man using cDNA probes that have been isolated from a rat pancreatic cDNA library. DNA from human × rodent somatic cell hybrids was cleaved with BamHI or EcoRI and analyzed by Southern filter hybridization methods for the segregation of the genes for trypsin-1 (TRY1), chymotrypsin B (CTRB), and elastase-1 (ELA1). TRY1 was assigned to human chromosome 7q22→qter, CTRB to chromosome 16, and ELA1 to chromosome 12. Although the three genes are members of the same gene family, they are dispersed over different chromosomes.
Original language | English (US) |
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Pages (from-to) | 369-376 |
Number of pages | 8 |
Journal | Somatic Cell and Molecular Genetics |
Volume | 10 |
Issue number | 4 |
DOIs | |
State | Published - Jul 1984 |
ASJC Scopus subject areas
- Genetics
- Cell Biology