Chromosomal Translocation in a Child with Chronic Lymphocytic Leukemia

Robert O. Dillman, R. Graham Smith, George A. Buchanan

Research output: Contribution to journalLetter

Abstract

To the Editor: Sonnier et al. (Sept. 8 issue)1 reported finding a chromosomal translocation involving the immunoglobulin kappalight-chain locus on chromosome 2 and the heavy-chain locus on chromosome 14 in a child with chronic lymphocytic leukemia. Their observations could certainly be relevant to any B-cell lymphoproliferative disorder. However, the authors make the point that a balanced 2p/14q translocation is an unexpected abnormality in chronic lymphocytic leukemia. In fact, Sadamori et al. found abnormalities of chromosome 12 to be particularly common in adult chronic lymphocytic leukemia.2 A large number of investigators have confirmed the presence of an antigen (T65) with a.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume310
Issue number7
DOIs
StatePublished - Feb 16 1984

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Genetic Translocation
B-Cell Chronic Lymphocytic Leukemia
Immunoglobulin Subunits
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 2
Lymphoproliferative Disorders
B-Lymphocytes
Research Personnel
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chromosomal Translocation in a Child with Chronic Lymphocytic Leukemia. / Dillman, Robert O.; Smith, R. Graham; Buchanan, George A.

In: New England Journal of Medicine, Vol. 310, No. 7, 16.02.1984.

Research output: Contribution to journalLetter

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