Chromosomal Translocation in a Child with Chronic Lymphocytic Leukemia

Robert O. Dillman, R. Graham Smith, George A. Buchanan

Research output: Contribution to journalLetter

Abstract

To the Editor: Sonnier et al. (Sept. 8 issue)1 reported finding a chromosomal translocation involving the immunoglobulin kappalight-chain locus on chromosome 2 and the heavy-chain locus on chromosome 14 in a child with chronic lymphocytic leukemia. Their observations could certainly be relevant to any B-cell lymphoproliferative disorder. However, the authors make the point that a balanced 2p/14q translocation is an unexpected abnormality in chronic lymphocytic leukemia. In fact, Sadamori et al. found abnormalities of chromosome 12 to be particularly common in adult chronic lymphocytic leukemia.2 A large number of investigators have confirmed the presence of an antigen (T65) with a.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume310
Issue number7
DOIs
StatePublished - Feb 16 1984

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ASJC Scopus subject areas

  • Medicine(all)

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